PMID: 45156Dec 1, 1979

Alkaline Phosphatase Activity Induction in Human Spleen Sinuses in Storage Diseases

Virchows Archiv. B, Cell Pathology Including Molecular Pathology
M Elleder


Human splenic sinuses were observed for the induction of alkaline phosphatase (AP) activity in mucopolysaccharidoses of type I and II, in GM1 gangliosidosis, and in Niemann-Pick's disease, type A. A substantially lower degree of activity was found in Sanfillipo's disease, type A, and in hemosiderin pigmentation of the sinuses. In a number of hematological affections and in control spleens AP activity could not be proved by histochemical means. From the formal pathogenetic view, enzyme activity induction is probably related to lysosomal deposition of the material stored.


Dec 1, 1979·Virchows Archiv. B, Cell Pathology Including Molecular Pathology·M Elleder
Aug 28, 1975·Histochemistry·M Borgers, F Thoné
Nov 1, 1977·American Journal of Clinical Pathology·K NanbaC W Berard
Dec 1, 1972·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·C Y LiW H Crosby
Jan 1, 1968·Zeitschrift für Zellforschung und mikroskopische Anatomie·H J Stutte
Nov 1, 1974·American Journal of Clinical Pathology·D P Rhone, F M White
May 1, 1974·The American Journal of Medicine·W H Fishman
May 1, 1972·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·M B Rufo, W H Fishman

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Niemann-Pick Diseases
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