PMID: 45156Dec 1, 1979

Alkaline Phosphatase Activity Induction in Human Spleen Sinuses in Storage Diseases

Virchows Archiv. B, Cell Pathology Including Molecular Pathology
M Elleder

Abstract

Human splenic sinuses were observed for the induction of alkaline phosphatase (AP) activity in mucopolysaccharidoses of type I and II, in GM1 gangliosidosis, and in Niemann-Pick's disease, type A. A substantially lower degree of activity was found in Sanfillipo's disease, type A, and in hemosiderin pigmentation of the sinuses. In a number of hematological affections and in control spleens AP activity could not be proved by histochemical means. From the formal pathogenetic view, enzyme activity induction is probably related to lysosomal deposition of the material stored.

Citations

Dec 1, 1979·Virchows Archiv. B, Cell Pathology Including Molecular Pathology·M Elleder
Aug 28, 1975·Histochemistry·M Borgers, F Thoné
Nov 1, 1977·American Journal of Clinical Pathology·K NanbaC W Berard
Dec 1, 1972·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·C Y LiW H Crosby
Jan 1, 1968·Zeitschrift für Zellforschung und mikroskopische Anatomie·H J Stutte
Nov 1, 1974·American Journal of Clinical Pathology·D P Rhone, F M White
May 1, 1974·The American Journal of Medicine·W H Fishman
May 1, 1972·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·M B Rufo, W H Fishman

Related Concepts

Gangliosidoses
Spleen
Mucopolysaccharidoses
Lysosomes
Niemann-Pick Diseases
Enzyme Induction
46, XY Sex Reversal 5
Alpha-L-Iduronidase Deficiency
Gangliosidosis GM1
Sulfoiduronate Sulfatase Deficiency

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Synapse Loss as Therapeutic Target in MS

As we age, the number of synapses present in the human brain starts to decline, but in neurodegenerative diseases this occurs at an accelerated rate. In MS, it has been shown that there is a reduction in synaptic density, which presents a potential target for treatment. Here is the latest research on synapse loss as a therapeutic target in MS.

Artificial Intelligence in Cardiac Imaging

Artificial intelligence (ai) techniques are increasingly applied to cardiovascular (cv) medicine in cardiac imaging analysis. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

Social Learning

Social learning involves learning new behaviors through observation, imitation and modeling. Follow this feed to stay up to date on the latest research.

Cell Atlas of the Human Eye

Constructing a cell atlas of the human eye will require transcriptomic and histologic analysis over the lifespan. This understanding will aid in the study of development and disease. Find the latest research pertaining to the Cell Atlas of the Human Eye here.

Single Cell Chromatin Profiling

Techniques like ATAC-seq and CUT&Tag have the potential to allow single cell profiling of chromatin accessibility, histones, and TFs. This will provide novel insight into cellular heterogeneity and cell states. Discover the latest research on single cell chromatin profiling here.

Genetic Screens in iPSC-derived Brain Cells

Genetic screening is a critical tool that can be employed to define and understand gene function and interaction. This feed focuses on genetic screens conducted using induced pluripotent stem cell (iPSC)-derived brain cells.