Jan 1, 1976

Alkaline phosphatase in the thymus

Acta Anatomica
M T RakhawyA M Zakaria


(1) Fetal thymuses, organs from patients who died from diseases that are not clinically known to be associated with concomitant lymphoid tissue involvement, as well as thymuses from patients dying from diseases which effect the lymphatic complex of the body, one way or another, have been investigated for their alkaline phosphatase activity, using Gomori technique and applying four different phosphate esters as substrates. (2) Three substrates (beta-glycerophophate, riboflavin 5-phosphate and adenosine triphosphate) showed essentially the same pattern of activity in which the cortex and Hassall's corpuscles were reactive, while the medulla was negative. A reversal of this pattern was demonstrated with 5-monophosphoric acid. (3) Before the age of 32-36 weeks of intra-uterine life there is no alkaline phosphatase activity in the thymus; therafter, the enzyme begins to make its first appearance. (4) There is a definite increase in the intensity of the reaction with advance of intra-uterine life. This increase in phosphatase content is continued postnatally, to reach its maximum at about the age of 10 years: after that, the enzyme activity gradually subsides. (5) There is a tremendous augmentation of phosphatase activity in the case...Continue Reading

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Mentioned in this Paper

Inborn Errors of Metabolism
Status Lymphaticus
Cortex Bone Disorders
Adrenal Cortex Diseases
Phosphoric Monoester Hydrolases
Entire Medulla Oblongata
Neoplasm of Uncertain or Unknown Behavior of Thymus
Alkaline Phosphatase Measurement

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