Alkaline phosphatase of the calf intestine hydrolyzes phospholipids

FEBS Letters
H EhleA Horn


Pure alkaline phosphatase of the calf intestine is able to hydrolyze phosphatidylinositol 4,5-diphosphate (TPI) to phosphatidylinositol and Pi and to dephosphorylate phosphatidic acid. This phosphomonoesterase activity shows a considerably high specific activity when an incubation medium at neutral pH containing 3 mM deoxycholate is used. The activity is inhibited by low concentrations of Ca2+. The enzyme has no detectable phosphodiesterase activity under the conditions tested.


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Related Concepts

Alkaline Phosphatase
Bos indicus
Phosphatidylinositol 4,5-Diphosphate

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