PMID: 42882Dec 20, 1979Paper

Alkaline stability of guanosine and some of its derivatives modified by the carcinogen N-acetoxyacetylaminofluorene

Nucleic Acids Research
M Spodheim-MaurizotM Leng

Abstract

The alkaline treatment of Guo, dGuo, dGMP and denatured DNA modified by N-acetoxyacetylaminofluorene (N-AcO-AAF) was performed in 0.1 M NaOH at 40 degrees C. The kinetics of the reaction were followed by ultraviolet absorption and by chromatographic methods and were found different for the four products under study. Circular dichroism spectra show differences in the environment of acetylaminofluorene residue in these products. The alkaline treatment of Guo-AAF (and dGuo-AAF) leads to the formation of three products. These products were separated by thin layer chromatography and by HPLC and were characterized by spectroscopic methods. One is the already known unstable Guo-AF (and respectively dGuo-AF) (1). The other two products are relatively stable products of the transformation of Guo-AF (or dGuo-AF). These last ones present almost identical ultraviolet absorption spectra, but very different circular dichroism spectra.

References

Apr 1, 1979·Nucleic Acids Research·M Spodheim-MaurizotM Leng
Nov 1, 1972·Proceedings of the National Academy of Sciences of the United States of America·B N AmesH Bartsch
Sep 9, 1974·Biochimica Et Biophysica Acta·E Kriek
Sep 22, 1965·Biochemical and Biophysical Research Communications·E Kriek

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Citations

Aug 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·E Sage, M Leng
Aug 1, 1991·Journal of Biomolecular Structure & Dynamics·L P van HouteR van Grondelle
Jul 24, 1982·Nucleic Acids Research·M Spodheim-MaurizotG Saint-Ruf
Oct 1, 1994·Environmental Health Perspectives·F JohnsonP L Yu
Mar 21, 2016·Mutation Research. Genetic Toxicology and Environmental Mutagenesis·Stefanie C FleckBeate Köberle
Oct 16, 1980·Biochemical and Biophysical Research Communications·M LengP Rio
Jan 1, 1980·Biochimie·P Rio, M Leng
Aug 1, 1989·Japanese Journal of Cancer Research : Gann·B BailleulM H Loucheux-Lefebvre
May 20, 1989·Journal of Molecular Biology·A SchwartzM Leng

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