Alkalinization of lidocaine 2% does not influence the quality of epidural anaesthesia for elective caesarean section

Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie
G GaggeroK Rifat

Abstract

This double-blind randomized study compared the effects of an epidural injection of lidocaine hydrochloride 2% (HCl) (Group 1), alkalinized lidocaine 2% (1 ml NaHCO3 per 10 ml of solution) injected either immediately (Group 2) or one hour after preparation (Group 3) in 45 parturients (n = 15 per group) scheduled for elective Caesarean section. Each patient received 16 ml of one of the three solutions. The mean pH values measured just before administration with a pH-meter PHM 64 Metrohm AG were 6.77 for the HCl lidocaine 2% solution, 7.34 for the freshly alkalinized solution and 7.35 for the solution prepared one hour before injection. The median maximal sensory level (range) observed was T3 (T8-C7), T4 (T5-C8) and T4 (T6-C6), obtained after 19 +/- 6 min, 18 +/- 8 min and 16 +/- 6 min respectively for each group. A motor block of grade 2 or 3 on the Bromage scale was obtained in 11, 10 and 14 patients respectively. No failure was observed although 3, 5, and 2 patients in Groups 1, 2, and 3 respectively required a supplementary bolus 20 min after the initial injection because of inadequate sensory level or pain at the operative site. In conclusion, this study shows that neither fresh alkalinization of 2% lidocaine nor the delay o...Continue Reading

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Citations

Dec 1, 1996·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·T KasabaM Takasaki
Dec 1, 1995·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·D H Morison
Aug 24, 2004·International Journal of Obstetric Anesthesia·R R GaiserB B Gutsche
Sep 1, 2000·The British Journal of Ophthalmology·M C MinasianC C Davey
Apr 12, 2000·European Journal of Anaesthesiology·Q J MilnerJ G Allen
May 23, 2015·The Cochrane Database of Systematic Reviews·M Soledad CepedaRoman Schumann
Mar 17, 2001·Bipolar Disorders·N A Levy, P G Janicak

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