Alkaloid presence and brine shrimp (Artemia salina) bioassay of medicinal species of eastern Nicaragua

Pharmaceutical Biology
Felix G CoeCaley A Johnson

Abstract

We used an alkaloid test and a brine shrimp bioassay to assess the bioactivity of the medicinal plants used by eastern Nicaraguan healers in traditional medicine. Ethnomedicinal uses were obtained from interviews of traditional healers. Aqueous extracts derived from 30 species of angiosperms were assayed for the presence of alkaloids and toxicity. Species tested are distributed in 30 genera and 21 families. Of the 30 species tested for alkaloids with Dragendorff's reagent, 29 contained alkaloids. Toxicological analysis was conducted using the brine shrimp lethal assay (BSLA). Biological activity using BSLA was recorded as the median lethal concentration (LC50) that kills 50% of the larvae within 24 h of contact with the aqueous plant extracts. The LC50 of the shrimp was less than 2500 microg/mL for 3 (10%) species, 2500-5000 microg/mL for 9 (30%), 5001-7500 microg/mL for 7 (23%), 7501-10000 microg/mL for 3 (10%), and greater than 10000 microg/mL for 8 (27%) of the species. The members of the orders Santales and Rubiales in general contained species with greater toxicity than any other group. Struthanthus cassythoides (Struthanthus cassythoides Millsp.(Loranthaceae)). (LC50 1574 microg/mL) and Alibertia edulis (Rich.) A. Rich. (...Continue Reading

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Jan 24, 2014·Evidence-based Complementary and Alternative Medicine : ECAM·Rainer W Bussmann
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Nov 8, 2016·Journal of Pharmaceutics·João Tavares Calixto-JúniorHenrique Douglas Melo Coutinho
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Jan 20, 2018·Chemistry Central Journal·Mazhar AbbasMunawar Iqbal
Dec 14, 2017·Evidence-based Complementary and Alternative Medicine : ECAM·Angel Josabad Alonso-CastroJuan Jose Maldonado-Miranda
Feb 10, 2020·Journal of Ethnopharmacology·Diana Figueiredo de Santana AquinoPriscila Neder Morato
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May 19, 2020·Journal of Ethnopharmacology·Luís Fernando Nunes Alves PaimSidnei Moura

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