ALKBH5-induced demethylation of mono- and dimethylated adenosine

Chemical Communications : Chem Comm
Timm T EnsfelderThomas Carell

Abstract

RNA contains methylated A-base derivatives. A methylation to m6A and then demethylation regulate homeostasis in mRNA. It is assumed that m6A is mainly demethylated by the α-ketoglutarate dependent oxidase ALKBH5. Here we show that ALKBH5 also demethylates the dimethylated adenosine m62A, which is a non-canonical base present in ribosomal RNA.

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Jul 10, 2020·Cellular and Molecular Life Sciences : CMLS·Baofang XuYongchun Zuo
Jun 26, 2020·Cell Death & Disease·Weifeng YaoZiqing Hei
Aug 4, 2020·Cancer Cell International·Jinyan WangQuan'an Zhang
Jan 30, 2021·Frontiers in Cell and Developmental Biology·Mahmoud Bayoumi, Muhammad Munir
Jun 8, 2021·Frontiers in Cellular Neuroscience·Justine MathouxGary P Brennan
Oct 12, 2021·The Journal of Biological Chemistry·Paulo A GameiroJernej Ule
Nov 19, 2021·Journal of Medicinal Chemistry·Gemma S PerryEsther C Y Woon

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