PMID: 7035923Oct 1, 1981Paper

Alkylating properties and genetic activity of 4-vinylcyclohexene metabolites and structurally related epoxides

Mutation Research
G TurchiA Abbondandolo

Abstract

The mutagenicity of the epoxides 4-vinyl-1,2-epoxycyclohexane, 4-epoxyethyl-1,2-epoxycyclohexane, 4-epoxyethyl-1,2-dihydroxycyclohexane, 1,2-epoxycyclohexane and styrene oxide was assayed on the TA100 strain of S. typhimurium and V79 Chinese hamster cells. In the latter cell system, both point mutation (6-thioguanine resistance) and chromosomal damage (anaphase bridges and micronuclei) were scored. Genetic effects were related to the alkylating properties of the epoxides. For this purpose, alkylation of 4-(p-nitrobenzyl)pyridine (NBP) and sodium-p-nitrothiophenolate (NTP) was measured and values for the substrate constant (s) were calculated. 4-Epoxyethyl-1,2-epoxycyclohexane, 1,2-epoxycyclohexane and styrene oxide, characterized by the highest reactivity toward NBP and by an s value in the vicinity of 1, were mutagenic in all test systems. 4-Vinyl-1,2-epoxycyclohexane and 4-epoxyethyl-1,2-dihydroxycyclohexane, characterized by lower NBP reactivity and higher s value (1.30-1.38), did not induce reversion in S. typhimurium or 6-thioguanine-resistant mutants in V79 cells, but were as effective as the 3 other compounds in the induction of chromosomal damage.

References

Nov 1, 1978·Mutation Research·D R WadeJ E Sinsheimer
Jan 1, 1979·Environmental Mutagenesis·M P Murray, J E Cummins
Jan 1, 1978·Chemico-biological Interactions·D H PhillipsP Sims
Jul 1, 1972·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·C T Bedford, J Robinson
Sep 1, 1970·Mutation Research·J VelemínskýL Ehrenberg
Jul 1, 1980·Mutation Research·V F Simmon, J M Baden

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Citations

Mar 1, 1991·Mutation Research·R Barale
Dec 1, 1994·Mutation Research·D Scott, R J Preston
Jul 1, 1994·Reproductive Toxicology·S B HooserI G Sipes
Aug 15, 1997·Journal of Chromatography. B, Biomedical Sciences and Applications·J BaoI G Sipes
Apr 7, 2012·Chemical Research in Toxicology·Rafael Gómez-BombarelliJulio Casado
Nov 23, 2012·Chemical Research in Toxicology·Marina González-PérezJulio Casado
Jan 1, 1983·Annals of the New York Academy of Sciences·D F Krahn
Sep 1, 1996·Journal of Applied Toxicology : JAT·S Dhillon, R Von Burg
Sep 15, 1990·Toxicology and Applied Pharmacology·B J SmithI G Sipes
Sep 15, 1990·Toxicology and Applied Pharmacology·B J SmithI G Sipes
Jun 4, 2021·Mutagenesis·Kerstin ReisingerRalph Pirow

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