Alkylation of 2-substituted (6-methyl-2-pyridyl)methyllithium species with epoxides.

The Journal of Organic Chemistry
James R VyvyanBrian P Woods

Abstract

Substituted (6-methyl-2-pyridyl)methyllithium species were reacted with 1,2-epoxyoctane and 2-methyl-2,3-epoxynonane. The monosubstituted epoxide reacted efficiently with lutidyllithium and a number of 2-substituted (6-methyl-2-pyridyl)methyllithium derivatives. The trisubstituted epoxide gave low yields of adducts with all (2-pyridyl)methyllithium species studied. These results are discussed in the context of a proposed synthesis of cananodine.

References

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Citations

May 9, 2012·Journal of Forensic Sciences·Christina KooMartin Johnston
Oct 8, 2013·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·Lida KhalafiSahar Fathi

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