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Alkylation of myotoxic phospholipases A2 in Bothrops moojeni venom: a promising approach to an enhanced antivenom production

The International Journal of Biochemistry & Cell Biology

Dec 4, 2003

Andreimar M SoaresJosé R Giglio

Abstract

Bothrops moojeni crude venom (MjCV) and its two major toxins, namely myotoxin I (MjTX-I) and myotoxin II (MjTX-II) were alkylated by p-bromophenacyl bromide (BPB). After alkylation the i.p. LD(50) (mice) of MjCV and MjTX-I/II increased from 6.0 to 15.7mg/kg and from 8.0 to 45.0mg/kg, re...read more

Mentioned in this Paper

Snake Venoms
Alpha-Neurotoxins
Myotoxin II, Bothrops moojeni
Toxin
Reptilian Proteins
Bothrops
Muscle Necrosis
Anasarca
Immunochemistry
Phospholipases A
Paper Details
References
  • References29
  • Citations16
123
  • References29
  • Citations16
12

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Alkylation of myotoxic phospholipases A2 in Bothrops moojeni venom: a promising approach to an enhanced antivenom production

The International Journal of Biochemistry & Cell Biology

Dec 4, 2003

Andreimar M SoaresJosé R Giglio

PMID: 14643891

DOI: 10.1016/s1357-2725(03)00237-1

Abstract

Bothrops moojeni crude venom (MjCV) and its two major toxins, namely myotoxin I (MjTX-I) and myotoxin II (MjTX-II) were alkylated by p-bromophenacyl bromide (BPB). After alkylation the i.p. LD(50) (mice) of MjCV and MjTX-I/II increased from 6.0 to 15.7mg/kg and from 8.0 to 45.0mg/kg, re...read more

Mentioned in this Paper

Snake Venoms
Alpha-Neurotoxins
Myotoxin II, Bothrops moojeni
Toxin
Reptilian Proteins
Bothrops
Muscle Necrosis
Anasarca
Immunochemistry
Phospholipases A

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Blastomycosis

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Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Related Papers

Toxicon : Official Journal of the International Society on Toxinology

Understanding the in vitro neuromuscular activity of snake venom Lys49 phospholipase A2 homologues

Toxicon : Official Journal of the International Society on ToxinologyOctober 31, 2009
M Gallacci, W L G Cavalcante
Toxicon : Official Journal of the International Society on Toxinology

Lysine 49 phospholipase A2 proteins

Toxicon : Official Journal of the International Society on ToxinologyMarch 18, 1999
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Paper Details
References
  • References29
  • Citations16
123
  • References29
  • Citations16
12
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