Alkylation reactions of phosphachroman-2,4-diones and 4-hydroxy phosphacoumarins

Bioorganic Chemistry
Xueshu LiYufen Zhao

Abstract

Phosphachroman-2,4-dione and 4-alkoxyphosphacoumarin derivatives, phosphonic analogues of chromones and coumarins with potential biological activities, were synthesized in good yields through sequential base-catalyzed intramolecular cyclization of O-alkyl-O'-(2'-methoxycarbonyl phenyl)-(substituted) benzyl phosphonates and alkylation. The synthesis sets the stage for an examination of the biological activities.

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Oct 21, 2005·Organic Letters·Xueshu LiYufen Zhao

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Citations

May 31, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ana I KolevaRositca D Nikolova

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