Alkylation-Terminated Catellani Reactions Using Alkyl Carbagermatranes

Angewandte Chemie
Wei-Tao JiangBin Xiao

Abstract

Catellani reaction has received extensive attentions as it allows rapid multiple derivatization on aromatics. While using alkyl electrophiles to achieve ortho -alkylation is one of the earliest features of Catellani reaction, beta -H incorporated ipso -alkylation terminated reaction has not been realized to date. Herein, we report alkylation terminated Catellani reaction using alkyl carbagermatranes (alkyl- Ge ) as nucleophiles. Reactivity of alkyl- Ge and alkyl-B(OH) 2 in this reaction was also discussed. This reaction realized efficient beta -H incorporated dialkylation, which is inaccessible by Catellani reaction before.

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Citations

Jan 20, 2021·Organic Letters·Cui-Tian WangYong-Min Liang
Apr 27, 2021·Chemical Communications : Chem Comm·Hajime KameoDidier Bourissou
Jun 5, 2021·Organic Letters·Aymane Selmani, Franziska Schoenebeck
Jul 29, 2021·Chemical Communications : Chem Comm·Shuo YangBin Xiao

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