All-cause mortality in relation to changes in relative blood volume during hemodialysis

Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association
Priscila PreciadoPeter Kotanko

Abstract

Relative blood volume (RBV) monitoring is widely used in hemodialysis (HD) patients, yet the association between intradialytic RBV and mortality is unknown. Intradialytic RBV was recorded once/min during a 6-month baseline period; all-cause mortality was noted during follow-up. RBV at 1, 2 and 3 h into HD served as a predictor of all-cause mortality during follow-up. We employed Kaplan-Meier analysis, univariate and adjusted Cox proportional hazards models for survival analysis. We studied 842 patients. During follow-up (median 30.8 months), 249 patients (29.6%) died. The following hourly RBV ranges were associated with improved survival: first hour, 93-96% [hazard ratio (HR) 0.58 (95% confidence interval (CI) 0.42-0.79)]; second hour, 89-94% [HR 0.54 (95% CI 0.39-0.75)]; third hour, 86-92% [HR 0.46 (95% CI 0.33-0.65)]. In about one-third of patients the RBV was within these ranges and in two-thirds it was above. Subgroup analysis by median age (≤/> 61 years), sex, race (white/nonwhite), predialysis systolic blood pressure (SBP; ≤/> 130 mmHg) and median interdialytic weight gain (≤/> 2.3 kg) showed comparable favorable RBV ranges. Patients with a 3-h RBV between 86 and 92% were younger, had higher ultrafiltration volumes and ra...Continue Reading

References

Feb 1, 1991·Kidney International·J T Daugirdas
Jul 1, 1994·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·R R SteuerJ M Conis
Apr 1, 1996·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·R R SteuerJ M Conis
Nov 20, 1998·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·A SantoroP Zucchelli
May 16, 2000·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·H P KrepelR Zietse
Nov 10, 2000·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·F M van der SandeK M Leunissen
Oct 17, 2001·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·J T Daugirdas
Dec 3, 2002·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Simeone AndrulliFrancesco Locatelli
Jun 17, 2003·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Claudia BarthJutta Passlick-Deetjen
Jun 3, 2005·Journal of the American Society of Nephrology : JASN·Donal N ReddanWilliam F Owen
Nov 16, 2007·Clinical Journal of the American Society of Nephrology : CJASN·Christopher W McIntyrePaolo G Camici
Jan 25, 2008·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Rajiv AgarwalRobert P Light
Jan 10, 2009·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Volker WizemannDaniele Marcelli
Sep 2, 2010·Nephron. Clinical Practice·John BoothAndrew Davenport
Jul 8, 2011·Clinical Journal of the American Society of Nephrology : CJASN·Bernard CanaudFriedrich K Port
Jan 19, 2012·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Charles ChazotVolker Wizemann
Oct 2, 2014·Journal of the American Society of Nephrology : JASN·Jennifer E FlytheSteven M Brunelli
Apr 12, 2015·Clinical Journal of the American Society of Nephrology : CJASN·Jennifer E FlytheSteven M Brunelli
Dec 9, 2015·Journal of Theoretical Biology·Aurelio A de los Reyes VPeter Kotanko
Jan 27, 2017·Journal of the American Society of Nephrology : JASN·Charlotte BuchananChris W McIntyre
Jul 1, 2018·Mathematical Biosciences·Victoria May E PaguioPeter Kotanko

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Citations

Feb 7, 2019·Clinical Journal of the American Society of Nephrology : CJASN·Indranil DasguptaHugh Rayner
Dec 28, 2018·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Peter Noel Van Buren
Mar 3, 2020·Hemodialysis International·Susanne KronJoachim Kron
Mar 13, 2020·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Bernard CanaudFrank Maddux
May 10, 2020·Therapeutic Apheresis and Dialysis : Official Peer-reviewed Journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy·Mototsugu TanakaNaobumi Mise
Sep 6, 2020·Current Opinion in Nephrology and Hypertension·Emily J See, Kevan R Polkinghorne
Aug 17, 2021·Hemodialysis International·Haekyung Jeon-SlaughterPeter Noel Van Buren

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