All-in-One Theranostic Nanoplatform Based on Hollow MoSx for Photothermally-maneuvered Oxygen Self-enriched Photodynamic Therapy

Theranostics
Jinping WangNan Li

Abstract

Photodynamic therapy (PDT) kills cancer cells by converting tumor-dissolved oxygen into reactive singlet oxygen (1O2) using a photosensitizer under laser irradiation. However, pre-existing hypoxia in tumors and oxygen consumption during PDT can result in an inadequate oxygen supply, which in turn hampers PDT efficacy. Herein, an O2 self-sufficient nanotheranostic platform based on hollow MoSx nanoparticles (HMoSx) with oxygen-saturated perfluorohexane (O2@PFH) and surface-modified human serum albumin (HSA)/chloride aluminium phthalocyanine (AlPc) (O2@PFH@HMoSx-HSA/AlPc), has been designed for the imaging and oxygen self-enriched photodynamic therapy (Oxy-PDT) of cancer. The in vitro anti-cancer activity and intracellular 1O2 generation performance of the nanoparticles were examined using 4T1 cells. We also evaluated the multimodal imaging capabilities and anti-tumor efficiency of the prepared nanoparticles in vivo using a 4T1 tumor-bearing nude mouse model. This nanoplatform could achieve the distinct in vivo fluorescence (FL)/photoacoustic (PA)/X-ray computed tomography (CT) triple-model imaging-guided photothermally-maneuvered Oxy-PDT. Interestingly, the fluorescence and Oxy-PDT properties of O2@PFH@HMoSx-HSA/AlPc were consid...Continue Reading

Citations

May 29, 2018·Angewandte Chemie·Xingshu LiJuyoung Yoon
Nov 2, 2019·Pharmaceuticals·Ludivine LarueCéline Frochot
Feb 20, 2021·ACS Applied Materials & Interfaces·Dongmiao SangFengyu Qu
May 15, 2021·Advanced Materials·Sheng WangXiaoyuan Chen
May 18, 2021·Frontiers in Cell and Developmental Biology·Haiyang WuZhiming Sun
Jun 14, 2021·Advances in Colloid and Interface Science·Marie Pierre Krafft, Jean G Riess
Jul 28, 2020·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Bo YangLin Chen
Aug 5, 2021·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Zhaoguo HanZhanhong Wu
Sep 21, 2019·ACS Nano·Lichan ChenJibin Song
Jan 20, 2021·ACS Biomaterials Science & Engineering·Qiang ZengJie Liu

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Methods Mentioned

BETA
X-ray
fluorescence microscopy
flow cytometry
transmission electron microscopy
transmission
infrared
circular dichroism
fluorescence
irradiate

Software Mentioned

SmartView

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