All natural cellulose acetate-Lemongrass essential oil antimicrobial nanocapsules

International Journal of Pharmaceutics
Ioannis L LiakosAthanassia Athanassiou

Abstract

Nanocapsules and nanoparticles play an essential role in the delivery of pharmaceutical agents in modern era, since they can be delivered in specific tissues and cells. Natural polymers, such as cellulose acetate, are becoming very important due to their availability, biocompatibility, absence of toxicity and biodegradability. In parallel, essential oils are having continuous growth in biomedical applications due to the inherent active compounds that they contain. A characteristic example is lemongrass oil that has exceptional antimicrobial properties. In this work, nanocapsules of cellulose acetate with lemongrass oil were developed with the solvent/anti-solvent method with resulting diameter tailored between 95 and 185nm. Various physico-chemical and surface analysis techniques were employed to investigate the formation of the nanocapsules. These all-natural nanocapsules found to well bioadhere to mucous membranes and to have very good antimicrobial properties at little concentrations against Escherichia coli and Staphylococcus aureus.

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Citations

Apr 23, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ioannis L LiakosPier Paolo Pompa
Jul 12, 2016·Pharmaceuticals·Ioannis L LiakosAthanassia Athanassiou
Apr 19, 2017·Nanomaterials·Ioannis L LiakosAlexandru Mihai Grumezescu
Mar 2, 2018·International Journal of Molecular Sciences·María L Zambrano-ZaragozaDavid Quintanar-Guerrero
Oct 20, 2018·Frontiers in Bioengineering and Biotechnology·Giulia SuaratoAthanassia Athanassiou

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