All-or-none population bursts temporally constrain surround inhibition between mouse olfactory glomeruli

Brain Research Bulletin
Cristina H ShirleyPhilip M Heyward

Abstract

With each sniff, the olfactory bulbs of the brain generate a neural activity pattern representing the odour environment, transmitting this to higher brain centres in the form of mitral cell output. Inhibitory circuits in the olfactory bulb glomerular and external plexiform layers may amplify contrast in these patterns, through surround inhibition of mitral cells. These circuits may operate in series, but their respective roles are unclear. A single sniff is sufficient for odour discrimination, but is not clear that the inhibitory circuits act within this timeframe. We used microdissected slices of mouse olfactory bulb to study each circuit in isolation. We found that unlike surround inhibition mediated in the external plexiform layer, surround inhibition mediated in the glomerular layer was activated by sensory synaptic input, but not by mitral cell output. The results also suggest that interactions between olfactory glomeruli are exclusively inhibitory, unlike in antennal lobe, and that surround inhibition mediated within the external plexiform layer may involve neural circuit elements not preserved in slice preparations. Surround inhibition was effective only after an interval corresponding to a single sniff in vivo. Surplus ...Continue Reading

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Citations

Apr 27, 2002·Studies in Family Planning·Jason L Finkle, C Alison McIntosh
May 18, 2012·Journal of Neurophysiology·Zuoyi ShaoMichael T Shipley
Jan 25, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jennifer D WhitesellNathan E Schoppa
Feb 15, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Shaolin LiuMichael T Shipley
Sep 13, 2014·The European Journal of Neuroscience·Sara BonzanoSilvia De Marchis
Jul 21, 2017·Journal of Neurophysiology·Shawn D Burton
Aug 13, 2011·Journal of Neurophysiology·Kajsa M IgelströmPhilip M Heyward
Aug 9, 2013·Journal of Neurophysiology·Zuoyi ShaoMichael T Shipley
Jan 30, 2020·Journal of Neurophysiology·Fu-Wen ZhouAdam C Puche

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