All-Silica Submicrometer Colloidosomes for Cargo Protection and Tunable Release

Angewandte Chemie
Hang JiangTo Ngai

Abstract

Colloidosomes have received considerable attention for the controlled delivery of active ingredients in medicine, agrochemicals, and cosmetics. However, most reported colloidosomes are highly permeable and size is larger than 1 μm. All silica colloidosomes have now been prepared with adjustable size, compact shell and low permeability. Our approach is based on the formation of inverse water-in-oil (w/o) emulsions stabilized solely by hydrophobic silica nanoparticles and subsequent locking of the particle at the oil-water interface by a simple sol-gel reaction of silica precursor at room temperature. The colloidosomes obtained display a robust and closed shell, ensuring a long-term retention of small hydrophilic molecules such as Methylene Blue. Remarkably, unlike all other reported silica colloidosomes, a timely and stepwise release of the encapsulated cargo can be triggered by adding ethanol or surfactant without destroying the capsule shell.

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Citations

Apr 25, 2019·Nature Communications·Xia RongHengquan Yang
Jan 7, 2021·Langmuir : the ACS Journal of Surfaces and Colloids·Michael Graham, Dmitry Shchukin
Feb 19, 2019·Journal of the American Chemical Society·Xiaoming ZhangHengquan Yang
Oct 16, 2020·Langmuir : the ACS Journal of Surfaces and Colloids·Hiroki MatsubaraBruce M Law
Dec 18, 2020·Langmuir : the ACS Journal of Surfaces and Colloids·Saul J HunterSteven P Armes
Oct 5, 2021·Journal of the American Chemical Society·Danping TianHengquan Yang
Dec 8, 2021·ACS Applied Materials & Interfaces·Changyue XuKunlin Chen

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