All-trans retinoic acid and intra-amniotic endotoxin-mediated effects on fetal sheep lung.

The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology
Boris W KramerAlan H Jobe

Abstract

All-trans retinoic acid (RA) is a potent modulator of lung development. Chorioamnionitis, which is frequently associated with preterm birth, causes fetal lung inflammation and improves lung function but also results in alveolar simplification and microvascular injury. Endotoxin-mediated chorioamnionitis reduces RA concentration in the fetal lung to 16% of control values. We hypothesized that administration of RA to the fetus before induction of chorioamnionitis would preserve septation of the distal airspaces. Time-mated ewes with singletons were assigned to receive a fetal intramuscular treatment with 20,000 IU of RA in olive oil (or olive oil only) 3 hr prior to intra-amniotic injection of endotoxin (20 mg, E. coli 055:B5) or saline, at 124-day gestational age and 7 days after the fetal treatment. The right cranial lung lobe was processed for morphometric analysis. RA treatment did not affect chorioamnionitis-induced fetal and systemic inflammation or interleukin-8 concentrations in lung tissue. RA administration alone did not alter lung structure. Relative to control lungs (5 +/- 3 mL/kg), lung volume increased similarly with endotoxin (22 +/- 4 mL/kg) or RA plus endotoxin (20 +/- 3 mL/kg; P < 0.05). Alveolar wall thickness ...Continue Reading

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Citations

Oct 12, 2010·American Journal of Physiology. Lung Cellular and Molecular Physiology·Jennifer J P CollinsBoris W Kramer
Sep 11, 2012·American Journal of Physiology. Lung Cellular and Molecular Physiology·Jennifer J P CollinsBoris W Kramer
Jan 21, 2014·Pediatric Research·Verena A LambermontBoris W Kramer
Mar 13, 2014·Birth Defects Research. Part A, Clinical and Molecular Teratology·Jennifer J P Collins, Bernard Thébaud
Jul 20, 2011·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Zeynep Alpay SavasanSonia S Hassan
Apr 15, 2016·Molecular and Cellular Pediatrics·Matthias C HüttenBoris W Kramer
Jan 15, 2013·American Journal of Obstetrics and Gynecology·Steffen KunzmannBoris W Kramer
Jan 25, 2011·American Journal of Obstetrics and Gynecology·Andrea J X LeeBoris W Kramer
Dec 4, 2010·Mediators of Inflammation·Taketoshi NoguchiHiroshi Kobayashi
Jun 28, 2011·Neonatology·Boris W Kramer
Mar 15, 2015·American Journal of Physiology. Lung Cellular and Molecular Physiology·Kurt H Albertine

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