All-trans retinoic acid is capable of inducing folate receptor β expression in KG-1 cells.

Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine
Ying XuSuoqin Tang

Abstract

The high expression of folate receptor (FR) on cancer cells might be a potential target for cancer therapy. In this study, the FR-β expression and the modulation effect of all-trans retinoic acid (ATRA) in a number of cancer cell lines were analyzed. The gateway of ATRA activity on FR-β expression was further studied by a panel of retinoid activators and inhibitors. The results revealed that ATRA was capable of upregulating the expression of FR-β protein in KG-1 cells in a dosage-dependent manner, not in KG-1a, NB4, HL60, 293, L1210, JAR, and Hela cells. FR-β mRNA expression in KG-1 cells was higher when ATRA was present in culture medium at 10⁻⁶ mol/L for 5 days, and it went down to baseline when ATRA was removed from the medium, vice versa. The upregulation of FR-β expression in KG-1 cells by ATRA was not associated with cell proliferation and differentiation. In addition, activators of retinoid acid receptor (RAR)α and RARγ, CD336, and CD2781 also induced FR-β expression. The induction of FR-β expression by CD336 could be inhibited by RARγ antagonist CD2665; RARβ agonist CD-417 and CD-2314 as well as retinoid X receptor (RXR) agonist LG100364 could not induce FR-β expression. These results indicate that ATRA within a certain...Continue Reading

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Citations

Apr 5, 2018·Leukemia & Lymphoma·Ying ZhouAmittha Wickrema
Sep 8, 2016·Nature Communications·Antonios ChronopoulosArmando Del Río Hernández
May 18, 2016·Netherlands Heart Journal : Monthly Journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation·F van den BrinkA J Funke Kupper
Dec 17, 2020·Materials Science & Engineering. C, Materials for Biological Applications·Dandan WangXuenong Zhang
Apr 5, 2021·Journal of Controlled Release : Official Journal of the Controlled Release Society·Dan-Dan Wang, Xue-Nong Zhang

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