Abstract
The high expression of folate receptor (FR) on cancer cells might be a potential target for cancer therapy. In this study, the FR-β expression and the modulation effect of all-trans retinoic acid (ATRA) in a number of cancer cell lines were analyzed. The gateway of ATRA activity on FR-β expression was further studied by a panel of retinoid activators and inhibitors. The results revealed that ATRA was capable of upregulating the expression of FR-β protein in KG-1 cells in a dosage-dependent manner, not in KG-1a, NB4, HL60, 293, L1210, JAR, and Hela cells. FR-β mRNA expression in KG-1 cells was higher when ATRA was present in culture medium at 10⁻⁶ mol/L for 5 days, and it went down to baseline when ATRA was removed from the medium, vice versa. The upregulation of FR-β expression in KG-1 cells by ATRA was not associated with cell proliferation and differentiation. In addition, activators of retinoid acid receptor (RAR)α and RARγ, CD336, and CD2781 also induced FR-β expression. The induction of FR-β expression by CD336 could be inhibited by RARγ antagonist CD2665; RARβ agonist CD-417 and CD-2314 as well as retinoid X receptor (RXR) agonist LG100364 could not induce FR-β expression. These results indicate that ATRA within a certain...Continue Reading
References
Nov 3, 1992·Biochemical Pharmacology·X WangM Ratnam
Jun 20, 1998·Nucleic Acids Research·H WangM Ratnam
May 15, 1998·The Biochemical Journal·F ShenM Ratnam
Sep 24, 2004·Leukemia Research·Anna M RiceAlan C Sartorelli
Sep 9, 2005·Frontiers in Bioscience : a Journal and Virtual Library·Hala Elnakat, Manohar Ratnam
Mar 22, 2006·The Journal of Experimental Medicine·Hiromichi MatsushitaPier Paolo Pandolfi
May 3, 2006·Leukemia Research·Li-Yun LuoKui Wang
Jun 3, 2006·Cancer Research·Huiling Qi, Manohar Ratnam
Sep 5, 2006·Cancer Research·Yuhong ChenIgor B Roninson
Feb 29, 2008·Journal of Immunological Methods·Toshimi TanitaYasuko Nakano
Mar 6, 2008·Expert Opinion on Drug Delivery·Xiaobin ZhaoRobert J Lee
Jul 2, 2009·Molecular Cancer Therapeutics·Haimei ChenThomas V O'Halloran
Sep 3, 2009·Annals of the New York Academy of Sciences·Jurate SavickieneRuta Navakauskiene
Dec 19, 2009·Blood·Lionel AdèsUNKNOWN European APL Group
Dec 25, 2009·Leukemia·P L KropfD E Johnson
Mar 11, 2010·Blood·Yasuhiko SakoeNorio Komatsu
Mar 11, 2010·Methods in Molecular Biology·Sumith A Kularatne, Philip S Low
Citations
May 9, 2014·PloS One·Linda E KelemenPaula J Robson
Apr 11, 2014·BioMed Research International·J VarshosazM Rostami
Apr 5, 2018·Leukemia & Lymphoma·Ying ZhouAmittha Wickrema
Sep 8, 2016·Nature Communications·Antonios ChronopoulosArmando Del Río Hernández
May 18, 2016·Netherlands Heart Journal : Monthly Journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation·F van den BrinkA J Funke Kupper
Dec 17, 2020·Materials Science & Engineering. C, Materials for Biological Applications·Dandan WangXuenong Zhang
Apr 5, 2021·Journal of Controlled Release : Official Journal of the Controlled Release Society·Dan-Dan Wang, Xue-Nong Zhang