Allatostatin C modulates nociception and immunity in Drosophila

Scientific Reports
Nathaniel D BachtelIoannis Eleftherianos

Abstract

Bacterial induced inflammatory responses cause pain through direct activation of nociceptive neurons, and the ablation of these neurons leads to increased immune infiltration. In this study, we investigated nociceptive-immune interactions in Drosophila and the role these interactions play during pathogenic bacterial infection. After bacterial infection, we found robust upregulation of ligand-gated ion channels and allatostatin receptors involved in nociception, which potentially leads to hyperalgesia. We further found that Allatostatin-C Receptor 2 (AstC-R2) plays a crucial role in host survival during infection with the pathogenic bacterium Photorhabdus luminescens. Upon examination of immune signaling in AstC-R2 deficient mutants, we demonstrated that Allatostatin-C Receptor 2 specifically inhibits the Immune deficiency pathway, and knockdown of AstC-R2 leads to overproduction of antimicrobial peptides related to this pathway and decreased host survival. This study provides mechanistic insights into the importance of microbe-nociceptor interactions during bacterial challenge. We posit that Allatostatin C is an immunosuppressive substance released by nociceptors or Drosophila hemocytes that dampens IMD signaling in order to ei...Continue Reading

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Citations

Sep 24, 2019·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Thang M KhuongG Gregory Neely
Sep 24, 2019·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Shelley A Adamo, Laura E McMillan
Dec 23, 2019·Biochemical and Biophysical Research Communications·Michael J Rizzo, Erik C Johnson
Feb 26, 2021·Developmental and Comparative Immunology·Zhanning XuHaihui Ye
Jun 25, 2021·Science Advances·Jennifer M PolinskiAndrea G Bodnar

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Methods Mentioned

BETA
transgenic

Software Mentioned

GraphPad Prism

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