Allele and extended haplotype polymorphism of HLA-A, -C, -B, -DRB1 and -DQB1 loci in Polish population and genetic affinities to other populations

Tissue Antigens
J NowakA Lange

Abstract

Human leukocyte antigen (HLA)-A, -C, -B, -DRB1 and -DQB1 alleles were typed in 200 Polish healthy volunteers recruited for stem cell donor registry, using sequence-specific primer (SSP) and direct sequencing-based methods. Enhanced Bayesian approach of expectation maximization algorithm provided by phase platform was used for extended HLA haplotype inferences. The numbers of identified alleles (four-digit resolution) were 23, 23, 44, 27 and 18 alleles in HLA-A, -C, -B, -DRB1 and -DQB1 loci, respectively, of both northern and southern European frequency characteristics. The most frequent extended haplotypes were Cw*0701-B*0801-DRB1*0301-DQB1*0201 and Cw*0702-B*0702-DRB1*1501-DQB1*0602, found in 25 and 23 copies, respectively, in 400 tested chromosomes. The extended haplotype found in the Polish population with higher frequency than in other European population was A*2501-Cw*1203-B*1801-DRB1*1501-DQB1*0602 (six copies) and especially its class I fragment (14 copies). The neighbour-joining and correspondence analyses showed Central and northern European genetic affinities of Polish population. In most cases, the observed European allele and haplotype gradients display smooth topography around Polish population. Poles along with We...Continue Reading

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Citations

Mar 29, 2011·Archivum Immunologiae Et Therapiae Experimentalis·Jacek NowakBarbara Zupańska
Feb 3, 2009·Rheumatology International·Markéta FojtíkováMarie Cerná
Sep 27, 2013·PloS One·Alexander H SchmidtGerhard Ehninger
May 20, 2009·Pharmacogenomics·Clive Bowman, Olivier Delrieu
Apr 13, 2013·Immunogenetics·Aimee M MerinoBrahim Aissani
Apr 11, 2012·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·Faraz BishehsariDavid C Whitcomb
Sep 25, 2012·Gene·Sara KhansaRami A R Mahfouz
Jul 4, 2012·Gene·Sara KhansaRami A R Mahfouz
Oct 26, 2010·Transplantation Proceedings·J NowakB Zupanska
Jul 31, 2010·Tissue Antigens·E C CastelliE A Donadi
Jul 22, 2014·American Journal of Hematology·Jacek NowakUNKNOWN Polish Donor-Recipient Matching Study Group
Jan 27, 2015·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Jacek NowakUNKNOWN Polish Donor-Recipient Matching Study Group
Sep 10, 2009·Tissue Antigens·H-Y ZouL-H Cheng
Aug 6, 2009·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Brahim AissaniRichard A Kaslow
Nov 26, 2008·Bone Marrow Transplantation·J Nowak
Apr 27, 2019·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Brahim AissaniSadeep Shrestha
Jan 6, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Alfonso Quintás-CardamaSusan O'Brien
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Dec 29, 2018·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Jonna ClancySatu Koskela

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