Allele and genotype frequencies of CYP2B6 and CYP2C19 polymorphisms in Egyptian agricultural workers.

Journal of Toxicology and Environmental Health. Part a
Corie A EllisonJames R Olson

Abstract

Genetic variability in cytochrome P-450 (CYP) has the potential to modify pharmacological and toxicological responses to many chemicals. Both CYP2B6 and CYP2C19 are pharmacologically and toxicologically relevant due to their ability to metabolize multiple drugs and environmental contaminants, including the organophosphorus (OP) pesticide chlorpyrifos. The aim of this study was to determine the prevalence of CYP2B6 and CYP2C19 variants in an indigenous Egyptian population (n = 120) that was shown to be occupationally exposed to chlorpyrifos. Further, the genotyping data was compared for Egyptians with previously studied populations to determine between population differences. Allelic frequencies were CYP2B6 1459C > T (3.8%), CYP2B6 785A > G (30.4%), CYP2B6 516G > T (28.8%), CYP2C19 681G > A (3.8%), and CYP2C19 431G > A (0%). The most prevalent CYP2B6 genotype combinations were CYP2B6 *1/*1 (44%), *1/*6 (38%), *6/*6 (8%), and *1/*5 (6%). The frequency of the CYP2C19 genotype combinations were CYP2C19 *1/*1 (93%), *1/*2 (6%), and *2/*2 (1%). The frequency of the CYP2B6 516G > T and CYP2B6 785A > G polymorphisms in this Egyptian cohort is similar to that found North American and European populations but significantly different from...Continue Reading

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Citations

Oct 25, 2014·Journal of Toxicology and Environmental Health. Part a·Dhananjay D ShindeDong-Hyun Kim
Oct 25, 2014·Journal of Toxicology and Environmental Health. Part a·Hyeon-Uk JeongHye Suk Lee
Jan 15, 2014·Drug Metabolism and Drug Interactions·Safaa Ossaily, Nathalie K Zgheib
Feb 25, 2014·Molecular Biology Reports·Nazan Yuce-ArtunH Sinan Suzen
Aug 31, 2018·Osong Public Health and Research Perspectives·Linawati Hananta Mustofa
Aug 28, 2019·Pharmacogenomics·Oluseye O BolajiBabatunde A Adeagbo

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