Allele frequencies at microsatellite loci: the stepwise mutation model revisited.

Genetics
A M ValdesN B Freimer

Abstract

We summarize available data on the frequencies of alleles at microsatellite loci in human populations and compare observed distributions of allele frequencies to those generated by a simulation of the stepwise mutation model. We show that observed frequency distributions at 108 loci are consistent with the results of the model under the assumption that mutations cause an increase or decrease in repeat number by one and under the condition that the product Nu, where N is the effective population size and u is the mutation rate, is larger than one. We show that the variance of the distribution of allele sizes is a useful estimator of Nu and performs much better than previously suggested estimators for the stepwise mutation model. In the data, there is no correlation between the mean and variance in allele size at a locus or between the number of alleles and mean allele size, which suggests that the mutation rate at these loci is independent of allele size.

Citations

May 26, 2001·Proceedings. Biological Sciences·S J RossiterE M Barratt
Mar 8, 2020·Theoretical Population Biology·John Wakeley
Apr 12, 2003·Theoretical Population Biology·Cecelia Laurie, B S Weir
Aug 28, 2007·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Suzanne M Cole, Jeffrey C Long
Feb 22, 2002·Molecular Ecology·François Balloux, Nicolas Lugon-Moulin
Oct 7, 2003·Annual Review of Genomics and Human Genetics·Sarah A Tishkoff, Brian C Verrelli
May 11, 2005·Human Genetics·Vania YotovaClaude Laberge
Dec 14, 2006·The Journal of Heredity·Maria KretzmannGeorge Amato
Jul 30, 2008·American Journal of Human Biology : the Official Journal of the Human Biology Council·Heather F Smith
Jun 1, 2005·TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik·Anne FrarySteven Tanksley
Apr 4, 2000·Genetics·R GonserA Di Rienzo
Oct 12, 2000·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·G K Chambers, E S MacAvoy
Jun 29, 2005·Journal of Molecular Evolution·Fabio PardiJohn C Whittaker
Apr 26, 2006·Journal of Plant Research·Chunlan L LianTaizo Hogetsu
Oct 19, 2004·Proceedings of the National Academy of Sciences of the United States of America·Claire VandiedonckHenri-Jean Garchon
Jun 6, 1996·Nature·W MessierC B Stewart
May 1, 1996·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·J M Hancock
Jun 1, 1996·Nature Medicine·D ShibataL A Aaltonen
Jan 1, 1996·International Journal of Legal Medicine·B BudowleR Chakraborty
May 23, 1998·American Journal of Human Genetics·R A KittlesJ C Long
Apr 13, 2000·Heredity·C G WilliamsR D Barnes
May 22, 1996·Proceedings. Biological Sciences·C RicoG Hewitt
Feb 7, 2008·Proceedings. Biological Sciences·Andrew B MunkacsiGeorgiana May
Apr 18, 2000·Electrophoresis·P WiegandB Brinkmann
Aug 1, 1996·Nature Genetics·C R PrimmerH Ellegren

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.