PMID: 11931575Apr 5, 2002Paper

Allele frequencies of apolipoprotein E gene polymorphisms in the protein coding region and promoter region (-491A/T) in a healthy Norwegian population

Human Biology
Theresa KumarSverre-Henning Brorson

Abstract

This study examines the distribution of apolipoprotein E (APOE) alleles in a population of healthy male and female Norwegians (n = 798) below the age of 40. The -491A/T polymorphism of the promoter region of the APOE gene was also examined. A seminested polymerase chain reaction was applied in the genotyping. The results showed that the E3 allele had the highest frequency (0.744), followed by E4 (0.198) and E2 (0.058). The APOE frequencies found in this study differ significantly from those obtained in earlier Norwegian APOE phenotypings. The allele frequencies in the -491 site of the promoter region were 0.845 for the A allele and 0.155 for the T allele. The genotype frequency was highest for AA (0.707), followed by AT (0.277) and TT (0.016). Moreover, the A allele was in linkage disequilibrium to E4.

Citations

Jan 25, 2005·Molecular Biology Reports·Abdulaziz A Al-Khedhairy
Jul 4, 2006·Molecular Biology Reports·Rami A R MahfouzGhazi S Zaatari
Feb 7, 2013·Developmental Medicine and Child Neurology·Espen LienJames A Blackman
Nov 10, 2006·Annals of Human Biology·P P SinghS S Mastana
Dec 5, 2009·International Journal of Geriatric Psychiatry·Jørgen WagleKnut Engedal
Jan 28, 2005·The Journal of Alternative and Complementary Medicine : Research on Paradigm, Practice, and Policy·Jae-Young UmSeung-Heon Hong
Dec 17, 2008·Genetic Testing·Argyri GialerakiAnthi Travlou
Aug 23, 2017·Journal of Alzheimer's Disease : JAD·Tormod FladbyDag Aarsland

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