Apr 20, 2020

Analysis of Pan-Omics Data in Human Interactome Network (APODHIN)

BioRxiv : the Preprint Server for Biology
N. BiswasSaikat Chakrabarti

Abstract

Analysis of Pan-Omics Data in Human Interactome Network (APODHIN) is a platform for integrative analysis of transcriptomics, proteomics, genomics, and metabolomics data for identification of key molecular players and their interconnections exemplified in cancer scenario. APODHIN works on a meta-interactome networks consisting of human protein-protein interactions, miRNA-target gene regulatory interactions, and transcription factor-target gene regulatory relationships, respectively. In its first module, APODHIN maps proteins/genes/miRNAs from different omics data in its meta-interactome network and extracts the network of biomolecules that are differentially altered in the given scenario. Using this context specific, filtered interaction network, APODHIN identifies topologically important nodes (TINs) implementing graph theory based network topology analysis and further justifies their role via pathway and disease marker mapping. These TINs could be used as prospective diagnostic and/or prognostic biomarkers and/or potential therapeutic targets. In its second module, APODHIN attempts to identify cross pathway regulatory and protein-protein interaction (PPI) links connecting signaling proteins, transcription factors, and miRNAs t...Continue Reading

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Mentioned in this Paper

The Cancer Genome Atlas
Genome
Synaptic Vesicles
MCF-7 Cells
Genomics
Weaver Syndrome
Genomic DNA
Structure
HelA protein, bacteria
Morphologically Altered Structure

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