PMID: 8995188Jan 1, 1997Paper

Allelic and interlocus comparison of the PERB11 multigene family in the MHC

Immunogenetics
S GaudieriR L Dawkins

Abstract

The major histocompatibility complex (MHC) contains at least a hundred genes over 4 megabases of DNA. Within the MHC there are several new multigene families which have been recently described. PERB11 is a multigene family which occurs over the class I and central region of the MHC. Two members of the family have been shown to be functional and share domains with members of the supergene family including HLA class I, FcRn, and Zn-alpha2-glycoprotein molecules. The two functional members are contained within an area of the MHC which has been associated with increased susceptibility to autoimmune diseases such as insulin-dependent diabetes mellitus and also rapid progression to AIDS following HIV-1 infection. Intralocus and interlocus differences between PERB11.1 and PERB11.2 include: (1) several nucleotide substitutions leading to amino acid changes; (2) presence and absence of potential glycosylation sites; (3) insertions and deletions leading to a frame shift resulting in diversity at the amino acid level and an early termination signal. There are ten different alleles of PERB11.1 including one allele which contains a frame shift in the transmembrane region causing a putative truncated molecule lacking the cytoplasmic tail. Th...Continue Reading

Citations

Jun 7, 2005·Human Immunology·Steven G E MarshJohn Trowsdale
Mar 8, 2002·European Journal of Immunogenetics : Official Journal of the British Society for Histocompatibility and Immunogenetics·E BolognesiP Momigliano-Richiardi
Nov 5, 1999·Vox Sanguinis·J G BodmerP I Terasaki
May 22, 2001·AIDS Patient Care and STDs·I Abdel-KhalekS Castells
Nov 7, 2001·Tissue Antigens·A V RomphrukH Inoko
Oct 18, 2000·Tissue Antigens·M OtaH Inoko
Apr 22, 2011·Annals of Human Biology·V DurmanováM Buc
Mar 25, 2005·International Journal of Immunogenetics·S G E MarshJ Trowsdale
Mar 25, 2005·Tissue Antigens·S G E MarshJ Trowsdale
Mar 21, 1998·Folding & Design·G ChelvanayagamR L Dawkins
Feb 25, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Yizhou ZouPeter Stastny
May 13, 1999·Tissue Antigens·J G BodmerP I Terasaki
May 20, 1999·European Journal of Immunogenetics : Official Journal of the British Society for Histocompatibility and Immunogenetics·S G Marsh
May 20, 1999·European Journal of Immunogenetics : Official Journal of the British Society for Histocompatibility and Immunogenetics·Z YaoE D Albert

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