Allelic diversity at the DLA-88 locus in Golden Retriever and Boxer breeds is limited.

Tissue Antigens
P RossP R Hess

Abstract

In the dog, previous analyses of major histocompatibility complex class I genes suggest a single polymorphic locus, dog leukocyte antigen (DLA)-88. While 51 alleles have been reported, estimates of prevalence have not been made. We hypothesized that, within a breed, DLA-88 diversity would be restricted, and one or more dominant alleles could be identified. Accordingly, we determined allele usage in 47 Golden Retrievers and 39 Boxers. In each population, 10 alleles were found; 4 were shared. Seven novel alleles were identified. DLA-88*05101 and *50801 predominated in Golden Retrievers, while most Boxers carried *03401. In these breeds, DLA-88 polymorphisms are limited and largely non-overlapping. The finding of highly prevalent alleles fulfills an important prerequisite for studying canine CD8+ T-cell responses.

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Citations

Jul 6, 2017·HLA : Immune Response Genetics·G M VenkataramanR Storb
Nov 27, 2018·ILAR Journal·Nana H OvergaardGregers Jungersen
Mar 12, 2019·Veterinary and Comparative Oncology·Paige S NemecPaul R Hess
Aug 12, 2016·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jin XiaoGeorge F Gao
Sep 17, 2020·Nature Reviews. Cancer·Amy K LeBlanc, Christina N Mazcko

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