PMID: 8606053Jan 1, 1996Paper

Allelic diversity at the primate Mhc-G locus: exon 3 bears stop codons in all Cercopithecinae sequences

Immunogenetics
M J CastroA Arnaiz-Villena

Abstract

Twenty-seven major histocompatibility complex (Mhc)-G exon 2, exon 3, and exon 2 and 3 allelic sequences were obtained together with 12 different intron 2 sequences. Homo sapiens, Pan troglodytes, Pan paniscus, Gorilla gorilla, Pongo pygmaeus, Macaca fascicularis, Macaca mulatta, and Cercopithecus aethiops individuals were studied. Polymorphism does not follow the classical pattern of three hypervariable regions per domain and is found in all species studied; exon 3 (equivalent to the alpha 2 protein domain) shows stop codons in the Cercopithecinae group but not in the Pongidae and human groups. Dendrograms show that cotton top tamarin (Saguinus oedipus) Mhc-G sequences are closer to Homo sapiens and Pongidae than to Cercopithecinae, probably due to the stop codons existing at exon 3 of the latter. There is a clear trans-species evolution of allelism in Cercopithecinae and also in exon 2 of all the other apes studied, but a generation of allelism within each species may be present on exon 3 sequences. This discrepancy may be due to the preferential use of exon 2 over exon 3 at the mRNA splicing level within each species in order to obtain the appropriate functional G product. Mhc-G intron 2 shows conserved motifs in all species...Continue Reading

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Citations

Nov 26, 2010·Cellular and Molecular Life Sciences : CMLS·Eduardo A DonadiPhilippe Moreau
May 19, 2005·Immunogenetics·Akihiko UdaAkio Yamada
Nov 28, 1997·Journal of Reproductive Immunology·T V HviidN Morling
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Sep 9, 1999·Journal of Reproductive Immunology·A Arnaiz-VillenaJ Martinez-Laso
Jan 4, 2001·Human Immunology·M J CastroA Arnaiz-Villena
Jan 4, 2001·Human Immunology·M J CastroA Arnaiz-Villena
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Mar 6, 2007·Immunogenetics·Nel OttingRonald E Bontrop
Aug 5, 2009·Human Immunology·Carlos Parga-LozanoAntonio Arnaiz-Villena
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Dec 13, 2006·Transplant Immunology·J MoscosoA Arnaiz-Villena
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Apr 3, 2021·International Journal of Immunogenetics·Antonio Arnaiz-VillenaJosé Manuel Fragoso
Feb 19, 2000·Molecular Phylogenetics and Evolution·Y SattaN Takahata
Aug 8, 2021·International Journal of Molecular Sciences·Anthony M Carter
Feb 28, 2002·Annual Review of Immunology·Carlos Vilches, Peter Parham

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