Allelic diversity of the MHC class II DRB genes in brown bears (Ursus arctos) and a comparison of DRB sequences within the family Ursidae

Tissue Antigens
Naoki GodaRyuichi Masuda

Abstract

The allelic diversity of the DRB locus in major histocompatibility complex (MHC) genes was analyzed in the brown bear (Ursus arctos) from the Hokkaido Island of Japan, Siberia, and Kodiak of Alaska. Nineteen alleles of the DRB exon 2 were identified from a total of 38 individuals of U. arctos and were highly polymorphic. Comparisons of non-synonymous and synonymous substitutions in the antigen-binding sites of deduced amino acid sequences indicated evidence for balancing selection on the bear DRB locus. The phylogenetic analysis of the DRB alleles among three genera (Ursus, Tremarctos, and Ailuropoda) in the family Ursidae revealed that DRB allelic lineages were not separated according to species. This strongly shows trans-species persistence of DRB alleles within the Ursidae.

References

Jan 1, 1990·Immunogenetics·U M Sarmiento, R Storb
Feb 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·A L Hughes, M Nei
Nov 29, 1994·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·A L HughesM Nei
Mar 21, 1998·Nature Genetics·T F BergströmU Gyllensten
Nov 10, 2001·Annual Review of Genomics and Human Genetics·A V Hill
Jul 24, 2002·Immunogenetics·Nel OttingRonald E Bontrop
Aug 20, 2002·Immunogenetics·Lorna J KennedyAlan D Radford
Oct 22, 2002·Immunogenetics·Jennifer M Seddon, Hans Ellegren
Dec 4, 2003·Developmental and Comparative Immunology·Helmut SchaschlFranz Suchentrunk
Feb 3, 2004·Journal of Animal Science·H Zhou, J G H Hickford
Mar 3, 2004·Proceedings of the National Academy of Sciences of the United States of America·Andres AguilarRobert K Wayne
Sep 29, 2005·Immunogenetics·Judith ReindersMarcel G J Tilanus
Apr 11, 2006·Zoological Science·Kosuke HayashiHiroko Koike
Jun 28, 2008·Journal of Molecular Evolution·Karin T Berggren, Jennifer M Seddon
Aug 1, 1998·Trends in Ecology & Evolution·S V Edwards, P W Hedrick

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