PMID: 6164059Dec 1, 1980Paper

Allelic forms of beta 2-microglobulin in the mouse

Proceedings of the National Academy of Sciences of the United States of America
J W Goding, I D Walker

Abstract

Spleen cells from BALB/c and C57BL/6 mice were cultured separately or together, and the biosynthetically labeled supernates were examined by two-dimensional polyacrylamide gel electrophoresis. Although there were no major labeled proteins in the mixed group that were not present in the separate cultures, there was a major low-molecular-weight protein that differed in charge in the two strains. This protein was identified as beta 2-microglobulin; it could be labeled with 125I on the cell surface by using the lactoperoxidase technique, was noncovalently attached to the H-2K molecule, and had the expected size and charge when compared with human beta 2-microglobulin. Both acidic and basic forms were present in (BALB/c X C57BL/6) F1 hybrids, suggesting codominant expression, although allelic exclusion was not ruled out. Either parental form could combine with one parental form of the H-2K molecule. The beta 2-microglobulin gene does not appear to be closely linked to either the H-2 or th immunoglobulin heavy-chain complexes. It is proposed that beta 2-microglobulin is an "effector subunit" of histocompatibility antigens and that its physiological role is to interact with a specific killing structure on the surface of cytolytic T ly...Continue Reading

References

Jul 1, 1976·The Journal of Experimental Medicine·E S VitettaJ W Uhr
Jan 1, 1977·Cold Spring Harbor Symposia on Quantitative Biology·C J BarnstableM J Crumpton
May 29, 1979·Biochemistry·F T GatesT J Kindt
Nov 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·F Hyafil, J L Strominger
Sep 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·H HengartnerE Müller
Jul 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·C M CroceH Koprowski
Jan 1, 1977·Cold Spring Harbor Symposia on Quantitative Biology·G M Edelman
Dec 2, 1977·Science·R Uy, F Wold
Nov 1, 1977·The Journal of Experimental Medicine·P P Jones
Jul 22, 1975·Biochemical and Biophysical Research Communications·T NatoriD Pressman
Jun 1, 1971·Archives of Biochemistry and Biophysics·J Cejka, M D Poulik
Dec 1, 1973·The Journal of Experimental Medicine·H M GreyJ L Strominger
Jul 1, 1972·Proceedings of the National Academy of Sciences of the United States of America·P A PetersonG M Edelman
Jul 1, 1980·Immunogenetics·J MichaelsonE A Boyse

❮ Previous
Next ❯

Citations

Jan 1, 1983·Immunogenetics·J Michaelson
Jan 1, 1981·Immunogenetics·S KimuraU Hämmerling
Jan 1, 1984·Immunogenetics·P J RobinsonK F Lindahl
Jul 1, 1982·Molecular Immunology·L GrafP J Robinson
Aug 1, 1983·Molecular Immunology·C Vincent, J P Revillard
Sep 1, 1996·Veterinary Immunology and Immunopathology·F HoshiS Kawamura
Aug 1, 1990·Toxicology Letters·G MorelJ de Ceaurriz
Jul 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·J W Goding, A W Harris
Dec 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·D MerueloA Rossomando
Mar 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·A ColombattiJ T August
Mar 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·D R CoxC J Epstein
Jan 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·Y BushkinE A Boyse
Nov 3, 2012·Developmental and Comparative Immunology·Rute D PintoNuno M S dos Santos
May 7, 1981·Nature·J E ColiganS G Nathenson
Mar 9, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Katharine E MagorPeter Parham
Sep 19, 2000·The Journal of Veterinary Medical Science·F HoshiS Kawamura

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.