Allelic imbalance and biochemical outcome after radical prostatectomy

Prostate Cancer and Prostatic Diseases
S R J BottM Williamson

Abstract

To compare the incidence of allelic imbalance (AI) in men with rapid disease progression with those who remained disease free after radical prostatectomy, with the aim of identifying genetic markers to predict prognosis and guide further treatment. Tumour and normal DNA were extracted from two matched groups of 31 men with extracapsular node-negative (pT3N0) prostate cancer who had undergone radical prostatectomy. One group comprised men who developed biochemical recurrence within 2 years of surgery and one group were prostate-specific antigen (PSA) free for at least 3 years. Men were matched for Gleason grade, preoperative PSA and pathological stage. Analysis was performed by genotyping. Allelic imbalance was analysed using 30 markers, and was seen in at least one marker in 57 (92%) of the cases. Deletion at marker D10S211 (10p12.1) was significantly more common in the relapse group than the non-relapse group (35 vs 5%, P=0.03). This study demonstrates significant association between AI on chromosome 10 and biochemical progression after radical prostatectomy.

References

Jan 1, 1992·Advances in Experimental Medicine and Biology·A A Sandberg
May 1, 1991·Genes, Chromosomes & Cancer·U S BergerheimP Ekman
Nov 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·B S CarterW B Isaacs
Oct 1, 1993·Genes, Chromosomes & Cancer·J A MacoskaS R Wolman
Jul 1, 1994·Genes, Chromosomes & Cancer·D MacGroganR Bookstein
Mar 28, 1997·International Journal of Cancer. Journal International Du Cancer·R DahiyaG Deng
Jul 17, 1997·International Journal of Cancer. Journal International Du Cancer·R DahiyaG Deng
Apr 3, 1999·International Journal of Cancer. Journal International Du Cancer·T SaricP O'Connell
May 11, 1999·JAMA : the Journal of the American Medical Association·C R PoundP C Walsh
May 20, 1999·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·M W KattanP T Scardino
Jul 11, 2000·Archives of Pathology & Laboratory Medicine·D G BostwickJ W Yarbro
Oct 6, 2000·Genes & Development·C Abate-Shen, M M Shen
Feb 24, 2001·CA: a Cancer Journal for Clinicians·W J CatalonaG F Carvalhal
Aug 16, 2001·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·D I QuinnP D Stricker
Jan 17, 2002·The Journal of Urology·Gerald W HullPeter T Scardino
Jan 29, 2002·The Prostate·Barbara LeubeBrigitte Royer-Pokora
Sep 23, 2003·The Journal of Urology·Gaëlle FromontOlivier Cussenot
Jan 11, 2005·BJU International·Simon R J BottM Constance Parkinson
Mar 12, 2005·BJU International·Fray F Marshall

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Citations

Nov 27, 2007·Cancer Genetics and Cytogenetics·Nicola Brookman-AmissahMark R Feneley

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