Allelic imbalance in mammary carcinomas induced by either 7,12-dimethylbenz[a]anthracene or ionizing radiation in rats carrying genes conferring differential susceptibilities to mammary carcinogenesis

Molecular Carcinogenesis
J D HaagM N Gould

Abstract

To identify and compare the genetic lesions associated with tumorigenesis in rats carrying the mammary carcinoma suppressor (MCS) 1 gene, we induced mammary carcinomas in (Wistar Furth (WF) x Copenhagen (Cop))F1 rats by using either 7,12-dimethylbenz[a]anthracene (DMBA) or radiation. The tumors were screened for allelic imbalances by using polymerase chain reaction and 65 polymorphic microsatellite markers spanning the genome. No allelic imbalance was detected at the mapped location of MCS-1 on chromosome 2; however, a scan of the genome revealed random allelic imbalances in the radiation-induced tumors. In addition, non-random loss of heterozygosity (LOH) on chromosome 1 in the DMBA-induced tumors was documented. We then screened three other subsets of DMBA- and radiation-induced mammary carcinomas from (WF x Fischer (F344))F1, (Wistar Kyoto x F344)F1, and (F344 x Cop)F1 rats for imbalance on chromosomes 1 and 2. No allelic imbalance was detected in the MCS-1 region of chromosome 2 in any of the tumors screened. Nonrandom imbalance on chromosome 1 was detected but only in the DMBA-induced tumors from the (F344 x Cop)F1 rats. Thus, only Cop-derived F1 rats have mammary tumors with the chromosome 1 imbalance; however, the imbala...Continue Reading

References

Jan 1, 1992·Cytogenetics and Cell Genetics·L S Gollahon, C M Aldaz
Jan 1, 1986·Annual Review of Genetics·A G Knudson
Jul 1, 1995·Molecular Carcinogenesis·G ManentiM A Pierotti
Oct 21, 1993·Nature·Y HaoB Tycko
Jan 1, 1995·Nature Genetics·H J JacobA Lernmark
May 9, 1995·Proceedings of the National Academy of Sciences of the United States of America·M A BrownE Solomon
Jan 1, 1995·Molecular Carcinogenesis·L S GollahonC M Aldaz
Apr 26, 1994·Proceedings of the National Academy of Sciences of the United States of America·R W WisemanP Söderkvist
Feb 1, 1994·Mammalian Genome : Official Journal of the International Mammalian Genome Society·J YamadaT Serikawa
Dec 1, 1995·Mutation Research·S SukumarY Chen
Jan 23, 1996·Proceedings of the National Academy of Sciences of the United States of America·S G FischerA Efstratiadis
Aug 1, 1996·Carcinogenesis·K S ChenM N Gould

❮ Previous
Next ❯

Citations

Sep 1, 1997·Mammalian Genome : Official Journal of the International Mammalian Genome Society·C SzpirerG Levan
Dec 17, 2004·Proceedings of the National Academy of Sciences of the United States of America·Jonathan J LiSara Antonia Li
Dec 4, 2002·Genes, Chromosomes & Cancer·Asa SjölingGöran Levan
Oct 16, 2016·Journal of Radiation Research·Kaye ShowlerYoshiya Shimada
Nov 26, 2002·International Journal of Cancer. Journal International Du Cancer·Jun-ichi TanumaMotoo Kitano
Jul 24, 2008·Molecular Carcinogenesis·Emma SamuelsonAfrouz Behboudi

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.