Allelic imbalance of insulin-like growth factor II gene expression in cancerous and precancerous lesions of the liver

Hepatology : Official Journal of the American Association for the Study of Liver Diseases
T AiharaS Imaoka

Abstract

Allelic imbalance of the insulin-like growth factor II (IGF II) gene expression is often seen in hepatocellular carcinoma (HCC). To investigate the role of allelic imbalance in hepatocarcinogenesis, we have studied allelic expression status of the IGF II gene in dysplastic nodules, which are precancerous lesions of HCC, as well as in HCCs of different histological grade, and the influence of the allelic imbalance on IGF II gene expression has also been examined. Allelic imbalance was observed in 3 of 7 dysplastic nodules, in 7 of 9 well-differentiated HCCs, and in 8 of 9 moderately differentiated HCCs. IGF II gene expression level, which was studied by a semiquantitative reverse-transcriptase polymerase chain reaction (RT-PCR), was significantly higher (3.6-fold) in the dysplastic nodules than the control livers, but a significant increase in the IGF II gene expression was not observed in well- and moderately differentiated HCCs as compared with the control livers. These results demonstrate that the allelic imbalance of the IGF II gene expression is seen in the early stage (precancerous lesions) of hepatocarcinogenesis. Association of the allelic imbalance with an increased expression of the IGF II gene in the precancerous lesi...Continue Reading

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Citations

Mar 6, 2010·Journal of Gastrointestinal Cancer·Marialuisa SorliniGiuseppe Romanelli
Oct 26, 2000·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M MaggioniM Roncalli
Jan 4, 2008·Journal of Gastroenterology and Hepatology·Carmen C-L Wong, Irene O-L Ng
May 29, 2001·Molecular Pathology : MP·J G ScharfG Ramadori
Sep 23, 2008·World Journal of Gastroenterology : WJG·Philippe CouvertNathalie Ganne-Carrié
Aug 1, 2007·Biomarkers in Medicine·Jeng-Eing JengJung-Fa Tsai
Apr 6, 2004·The Surgical Clinics of North America·Mark A FeitelsonZhaorui Lian
Apr 24, 2002·Oncogene·Mark A FeitelsonZhaorui Lian
Jan 17, 2009·The Journal of Pathology·Bart RikhofWinette T A van der Graaf
Dec 22, 1999·The Journal of Clinical Endocrinology and Metabolism·D Le Roith, A A Butler

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