PMID: 8589033Nov 1, 1995Paper

Allelic imbalance study of 16q in human primary breast carcinomas using microsatellite markers

Genes, Chromosomes & Cancer
F Dorion-BonnetM Longy

Abstract

The high incidence of allelic imbalance on the long arm of chromosome 16 in breast cancer suggests its involvement in the development and progression of the tumor. Several loss of heterozygosity (LOH) studies have led to the assignment of commonly deleted regions on 16q where tumor suppressor genes may be located. The most recurrent LOH regions have been 16q22.1 and 16q22.4-qter. The aim of this study was to gain further insight into the occurrence of one or multiple "smallest regions of overlap" on 16q in a new series of breast carcinomas. Hence, a detailed allelic imbalance map was constructed for 46 sporadic breast carcinomas, using 11 polymorphic microsatellite markers located on chromosome 16. Allelic imbalance of one or more markers on 16q was shown by 30 of the 46 tumors (65%). Among these 30 carcinomas, LOH on the long arm of chromosome 16 was detected at all informative loci in 19 (41%); 13 of them showed allelic imbalance on the long but not on the short arm, with the occurrence of variable "breakpoints" in the pericentromeric region. The partial allelic imbalance in 11 tumors involved either the 16q22.1-qter LOH region or interstitial LOH regions. A commonly deleted region was found between D16S421 and D16S289 on 16q...Continue Reading

References

Oct 29, 1992·Nature·J WeissenbachM Lathrop
Jun 1, 1992·Cancer Genetics and Cytogenetics·I PetkovićM Nakić
Jun 1, 1991·Cancer Genetics and Cytogenetics·P J HainsworthO M Garson
Nov 1, 1991·Breast Cancer Research and Treatment·B DutrillauxM Prieur
May 1, 1991·Genes, Chromosomes & Cancer·U S BergerheimP Ekman
Sep 1, 1990·Genes, Chromosomes & Cancer·C LarssonM Nordenskjöld
Oct 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·C S CroppR Callahan
Sep 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·H TsudaS Hirohashi
Nov 1, 1990·Genes, Chromosomes & Cancer·E L Mitchell, M F Santibanez-Koref
Sep 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·L C ChenH S Smith
Apr 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·C LundbergM Nordenskjöld
Apr 1, 1971·Proceedings of the National Academy of Sciences of the United States of America·A G Knudson
Nov 1, 1993·Genes, Chromosomes & Cancer·M A HulténC S Rodgers
Feb 1, 1994·Genes, Chromosomes & Cancer·A M Cleton-JansenC J Cornelisse
Jun 1, 1994·Nature Genetics·G GyapayJ Weissenbach
May 1, 1993·Genes, Chromosomes & Cancer·N Kokalj-VokacB Dutrillaux
May 1, 1994·Nature Genetics·J I RisingerJ Boyd
Mar 1, 1994·Proceedings of the National Academy of Sciences of the United States of America·T OdaS Hirohashi
Jan 15, 1994·International Journal of Cancer. Journal International Du Cancer·R KirchwegerC Theillet
Feb 1, 1993·Molecular Biology Reports·M J BussemakersJ A Schalken

❮ Previous
Next ❯

Citations

Jul 1, 1997·Genes, Chromosomes & Cancer·K DriouchR Lidereau
Oct 23, 1997·Genes, Chromosomes & Cancer·J S MorrisP A Edwards
Nov 4, 2000·International Journal of Cancer. Journal International Du Cancer·N G BürkiD C Ward
Mar 17, 2005·Breast Cancer Research and Treatment·Claudio Di CristofanoAndrea Cavazzana
May 10, 2001·Cancer Genetics and Cytogenetics·I J ChalmersM J Atkinson
Jun 6, 1998·Cancer Genetics and Cytogenetics·R Schneider-StockJ T Epplen
Aug 30, 2001·Trends in Genetics : TIG·R OhlssonV Lobanenkov
Nov 5, 2002·Critical Reviews in Oncology/hematology·F Lerebours, R Lidereau
Aug 3, 2004·Genes, Chromosomes & Cancer·Anne-Marie Cleton-JansenCees J Cornelisse
Apr 15, 2003·The Journal of Pathology·Rebecca RoylanceIan Tomlinson
Mar 7, 2006·Genes, Chromosomes & Cancer·Emad A RakhaIan O Ellis
Aug 17, 1999·Seminars in Cancer Biology·S Ingvarsson
Apr 12, 2007·American Journal of Rhinology·Alexander D KaratzanisGeorge A Velegrakis
Mar 31, 1999·British Journal of Cancer·A M Cleton-JansenC J Cornelisse
Jul 17, 1999·British Journal of Cancer·Y MoriA Horii
Jun 9, 1999·British Journal of Cancer·Z PiaoH Kim
Jul 11, 1997·The Journal of Biological Chemistry·J D WeberJ J Baldassare
Jun 1, 1997·Diagnostic Molecular Pathology : the American Journal of Surgical Pathology, Part B·M LongyD Moynet

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