PMID: 7932807Oct 19, 1994Paper

Allelic loss at chromosomes 3p, 8p, 13q, and 17p associated with poor prognosis in head and neck cancer

Journal of the National Cancer Institute
X LiP Nisen

Abstract

Little is known about the molecular genetic events that contribute to the pathogenesis of squamous cell carcinoma of the upper aerodigestive tract. Previous molecular genetic studies have been limited to the identification of mutations of the p53 (also known as TP53) tumor suppressor gene, activation of a limited set of oncogenes, allelic loss at 3p and other locations, and occasional association with human papillomavirus infection. Our purpose was to screen tumor tissue and blood from patients with squamous cell carcinoma of the upper aerodigestive tract for loss of heterozygosity at polymorphic loci corresponding to each of the autosomal chromosomes and to identify the locations of additional putative tumor suppressor genes, other than RB (also known as RB1) and p53, that may contribute to the pathogenesis of this disease. Tumor tissue and blood were obtained from 68 consecutive patients with squamous cell carcinoma of the upper aerodigestive tract. In all cases, tumor tissue was obtained from the center of the surgical specimen. The relative absence of non-neoplastic tissue was confirmed by frozen-section histologic examination of immediately adjacent tissue. Initially, 30 paired tissue and blood samples were tested for loss...Continue Reading

Citations

Sep 30, 1999·International Journal of Cancer. Journal International Du Cancer·V K GuptaS B Scholnick
Dec 22, 1999·International Journal of Cancer. Journal International Du Cancer·N HamelW D Foulkes
Feb 7, 2001·International Journal of Cancer. Journal International Du Cancer·C L RosenbergT L Delaney
May 8, 2000·International Journal of Cancer. Journal International Du Cancer·C ChoiB R Oh
Nov 5, 1997·Journal of Cellular Biochemistry·S MénardM E Sobel
Sep 18, 1997·Genes, Chromosomes & Cancer·J H Leonard, N Hayard
Aug 24, 2000·International Journal of Cancer. Journal International Du Cancer·S W ChoiM G Rhyu
Aug 15, 2000·Head & Neck·R C Poli-FredericoS R Rogatto
Dec 18, 2001·International Journal of Cancer. Journal International Du Cancer·A N RosenthalI J Jacobs
May 1, 1995·Seminars in Surgical Oncology·S P Schantz
Jan 1, 1995·Pathology Oncology Research : POR·Xiang Gao, Kenneth V Honn
Jul 1, 2009·Clinical & Experimental Metastasis·Wiktor SzewczukAndrzej Semczuk
Jul 1, 1996·European Journal of Cancer. Part B, Oral Oncology·E J MaoA M Beckmann
Apr 8, 1998·Cancer Genetics and Cytogenetics·A K el-NaggarJ G Batsakis
Mar 25, 2000·Cancer Genetics and Cytogenetics·F R GratiG Simoni
Mar 1, 2003·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·S MiyakisJ K Field
Apr 4, 1998·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·S B ScholnickM R Zequeira
Jul 27, 2002·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·R P HoggF Latif
Feb 13, 2001·Oral Oncology·S Jefferies, W D Foulkes
Jan 6, 2000·Oral Oncology·Y T JinA K el-Naggar
Aug 13, 2008·The Journal of Laryngology and Otology·F O AgadaJ Greenman
Mar 5, 1999·Breast Cancer Research and Treatment·S MénardM I Colnaghi
May 3, 2007·European Journal of Human Genetics : EJHG·Harlinde De SchutterSandra Nuyts
May 12, 2000·The Laryngoscope·L L Gleich
Sep 25, 2001·The Laryngoscope·J P RodrigoJ A Martínez
Jul 1, 1997·The Australian and New Zealand Journal of Surgery·C B ReidB J Braakhuis

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