Allelic loss of 6q25-27, the PARKIN tumor suppressor gene locus, in cervical carcinoma.

Medical Oncology
Syed Jafar MehdiM Moshahid Alam Rizvi

Abstract

Studies on loss of heterozygosity have been made for Parkin gene-specific microsatellite markers in malignancies like breast, ovary and lungs, and the results have shown a significant association. However, till date, there is no study with respect to Parkin gene-associated microsatellite markers in cervical cancer. The present study deals with the Parkin gene-associated microsatellite markers and the occurrence of its loss of heterozygosity in patients with human cervical cancer. DNA was isolated from the 105 cervical carcinoma samples and matched control specimens. Polymerase chain reaction was performed using primer specific for two intragenic markers D6S1599 and D6S305 present in Parkin introns 2 and 7, respectively, and one marker (D6S1008) at telomeric end and further electrophoresed on 8% denaturing polyacrylamide gel. Overall, 59 of 105 (56%) samples showed loss of heterozygosity in at least one locus in the region examined. The percentage of loss of heterozygosity for these markers ranged from 25% (D6S1008) to 48% (D6S305). Chi-square test was performed, and loss of heterozygosity was found significantly higher in both the intragenic markers (D6S1599 and D6S305) when compared with the locus at telomeric end (D6S1008) wi...Continue Reading

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Citations

May 6, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Sama F SleimanRajiv R Ratan
Jan 15, 2016·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Rehana QureshiMoshahid Alam Rizvi
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Mar 30, 2017·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Haifeng NiYong Li
Jun 21, 2017·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Afreen NaseemM Moshahid Alam Rizvi
Jan 20, 2018·Molecular Neurobiology·Khushnuma WahabiMoshahid A Rizvi
Jan 30, 2013·Molecular Carcinogenesis·Asgar AliMoshahid A Rizvi
Apr 1, 2021·Biochimica Et Biophysica Acta. Reviews on Cancer·Ahmad PerwezMoshahid A Rizvi
Jun 11, 2021·Biochemical Pharmacology·Fátima E Murillo-GonzálezGuillermo Elizondo
Sep 2, 2021·Journal of Gastrointestinal Cancer·Zafar Iqbal BhatM Moshahid Alam Rizvi

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