Allelic loss of chromosome 4q21 approximately 23 associates with hepatitis B virus-related hepatocarcinogenesis and elevated alpha-fetoprotein

Hepatology : Official Journal of the American Association for the Study of Liver Diseases
Shiou-Hwei YehPei-Jer Chen

Abstract

Allelic loss of chromosome 4q is one of the most frequent genetic aberrations found in human hepatocellular carcinoma (HCC) and suggests the presence of putative tumor suppressor genes within this region. To precisely define the region containing these tumor suppressor genes for further positional cloning, we tried a detailed deletion mapping strategy in 149 HCCs by using 49 microsatellite markers covering 4q12 approximately 25. A common region with allelic loss has been identified based on the interstitial deletions occurring within it; this region is found between D4S1534 and D4S1572 (a 17.5-cM genetic interval). When we included all cases with limited aberration regions for comparison, 2 smaller regions were derived: 1 between D4S1534 and D4S2460 (3.52 cM) and 1 between D4S2433 and D4S1572 (8.44 cM). A few candidate genes were found to be down-regulated in HCCs, but without sequence mutations. In these HCCs, 4q alleleic loss was associated with hepatitis B virus infection status and the elevation of serum alpha-fetoprotein (>/=400 ng/mL). In conclusion, the current study not only mapped a common allelic loss region on chromosome 4q, but it also revealed that its loss may be involved in hepatitis B virus-related hepatocarcino...Continue Reading

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Citations

May 27, 2005·Acta Pharmacologica Sinica·Sze-hang Lau, Xin-yuan Guan
Aug 14, 2012·International Journal of Cancer. Journal International Du Cancer·Wei-Hsiang LinPei-Jer Chen
Jun 7, 2008·American Journal of Medical Genetics. Part a·William B DobynsLisa G Shaffer
Jan 19, 2007·International Journal of Cancer. Journal International Du Cancer·Shiou-Hwei YehPei-Jer Chen
Jun 19, 2010·Orvosi hetilap·Alajos Pár

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