Allelic loss of DNA locus of the RET proto-oncogene in small cell lung cancer

Cancer Letters
Hitoyasu FutamiKen Yamaguchi

Abstract

We analyzed all 21 exons of the RET proto-oncogene of paired genomic DNA from tumors and normal tissues in 12 small cell lung cancer (SCLC) patients for the presence of genetic alteration. Polymerase chain reaction single-strand conformation polymorphism analysis and direct sequencing revealed that heterozygosity of the RET proto-oncogene was lost in the tumor tissues of six patients out of eight informative SCLC patients, although point mutation was not evident in any tumors. These results suggest that a deletion of the chromosomal region including the RET proto-oncogene is involved in the pathogenesis of SCLC.

References

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Citations

Feb 28, 2013·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Dorian R A SwartsErnst-Jan M Speel
Jul 3, 2004·Cancer Research·Shirley M Myers, Lois M Mulligan

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