Allelic loss on chromosomes 2q21 and 19p 13.2 in oxyphilic thyroid tumors

International Journal of Cancer. Journal International Du Cancer
K StankovGiovanni Romeo

Abstract

Hürthle thyroid tumors are characterized by frequent numerical chromosomal aberrations, including aneuploidy or polyploidy, losses and gains of some chromosomal regions and DNA fragmentation. In recent years, great attention has been paid to the combined analysis of morphologic and genetic features of oxyphilic tumors and to the elucidation of their pathogenesis. We analyzed for loss of heterozygosity (LOH) of the candidate regions for TCO (thyroid tumor with cell oxyphilia) and NMTC1 (nonmedullary thyroid carcinoma 1), 2 loci already mapped on chromosomes 19p13.2 and 2q21, respectively. Matched normal and tumor DNA samples from 70 patients with sporadic oxyphilic thyroid tumors and 20 with sporadic follicular tumors were subjected to microsatellite analysis using 10 markers on 19p13.2 and 6 markers on 2q21. This approach led us to the observation of a more significant LOH in oxyphilic than in follicular tumors. Allelic loss in tumor samples was evenly distributed in both 19p13.2 and 2q21 regions, in accordance with the established linkage of TCO and NMTC1 for inherited tumors. In order to investigate the possible contribution of both susceptibility loci in oxyphilic tumors, the family that led to the original mapping of TCO lo...Continue Reading

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Citations

May 15, 2010·Thyroid : Official Journal of the American Thyroid Association·Ayesha KhanKate Newbold
Jun 6, 2013·Thyroid : Official Journal of the American Thyroid Association·Haggi Mazeh, Rebecca S Sippel
Apr 20, 2012·Endocrine-related Cancer·Valdemar MáximoManuel Sobrinho-Simões
Dec 7, 2007·World Journal of Surgery·Electron Kebebew
Feb 27, 2010·Molecular and Cellular Endocrinology·Giuseppe GasparreGiovanni Romeo
Sep 5, 2006·Surgical Oncology·Nancy M Carroll, Sally E Carty
Oct 30, 2014·Journal of Surgical Oncology·Kathryn J Rowland, Jeffrey F Moley
Nov 4, 2016·Endocrine-related Cancer·Samantha Peiling Yang, Joanne Ngeow
May 7, 2010·International Journal of Surgical Pathology·Hugo PrazeresManuel Sobrinho-Simões
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Sep 18, 2020·Briefings in Bioinformatics·J P Torcivia, R Mazumder
Jun 1, 2006·Cancer Control : Journal of the Moffitt Cancer Center·Carl D Malchoff, Diana M Malchoff
Jan 27, 2021·Endocrine Pathology·José Manuel Cameselle-TeijeiroVirginia LiVolsi

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