Allelic losses at chromosome 3p are seen in human papilloma virus 16 associated transitional cell carcinoma of the cervix

Gynecologic Oncology
A MaitraJ Albores-Saavedra

Abstract

Transitional cell carcinomas (TCCs) of the cervix are rare neoplasms of the female genital tract. Although these tumors display urothelial differentiation, there is controversy regarding their histogenetic relationship to squamous cell carcinomas (SCC) of the cervix versus transitional cell carcinomas of the bladder. We performed partial allelotyping of five TCCs of the cervix using 23 polymorphic markers located on chromosomes 3p and 9, which demonstrate frequent and early losses in cervical SCC and urothelial TCC, respectively. Multiplex polymerase chain reaction was used on DNA extracted from archival paraffin-embedded tissue using precise microdissection. Additionally, P53 gene mutation analysis was performed using single-strand confirmation polymorphism (SSCP) and the presence of human papilloma virus (HPV) sequences was analyzed using general and specific (types 16 and 18) primers. General HPV sequences were demonstrated in all cases, but the oncogenic strain HPV 16 was present in only three (60%) of the five tumors; no HPV 18 was detected in any sample. Three of five TCCs, all harboring HPV 16 sequences, demonstrated concurrent allelic losses at several 3p loci (specifically 3p12, 3p14.2 [the FHIT gene locus], 3p21.3, an...Continue Reading

References

Aug 16, 1995·Journal of the National Cancer Institute·Y KishimotoA F Gazdar
Nov 8, 1994·Proceedings of the National Academy of Sciences of the United States of America·A OkamotoD H Beach
Dec 20, 1995·International Journal of Cancer. Journal International Du Cancer·L ThibervilleG Nouvet
Jul 1, 1995·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·R W ThomasonH Dave
Feb 1, 1996·Gynecologic Oncology·G W SpiegelP L Gelven
Jul 1, 1997·American Journal of Obstetrics and Gynecology·D M GershensonE G Silva
Aug 1, 1997·The American Journal of Surgical Pathology·C KoenigF A Tavassoli
Dec 31, 1997·Science·R F BonnerL A Liotta
Feb 14, 1998·British Journal of Cancer·A M KersemaekersM J van de Vijver
Feb 14, 1998·International Journal of Cancer. Journal International Du Cancer·T Y ChuH S Liu
Feb 25, 1998·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·M van BeurdenJ ter Schegget
May 1, 1998·Human Pathology·J J O'LearyC T Doyle
May 20, 1998·Genes, Chromosomes & Cancer·J S RaderP C Huettner
May 30, 1998·JAMA : the Journal of the American Medical Association·I I WistubaA F Gazdar
Jun 24, 1998·Proceedings of the National Academy of Sciences of the United States of America·J W FondonH R Garner
Aug 15, 1998·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·I LombardX Sastre-Garau

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Citations

Oct 19, 2004·Clinical Microbiology Reviews·Jennifer L Edwards, Michael A Apicella
Jun 26, 2014·Archives of Medical Research·Giovanna E CarpagnanoMaria P Foschino-Barbaro
Mar 1, 2011·Surgical Pathology Clinics·Kay J Park
Sep 16, 2011·The Journal of Obstetrics and Gynaecology Research·Bernhard NiederleArnd Honig
Dec 5, 2006·Seminars in Cancer Biology·David I SmithDamon S Perez
Jun 24, 2003·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Claudius E RobinsonJorge Albores-Saavedra
Jul 27, 2005·Journal of Lower Genital Tract Disease·Peter A DrewDaylene L Ripley
Jan 1, 2015·Nature Reviews. Disease Primers·Helen DimarasBrenda L Gallie
Jan 5, 2002·Applied Immunohistochemistry & Molecular Morphology : AIMM·Y ManF A Tavassoli
Jun 27, 2019·Journal of Pathology and Translational Medicine·Yangkyu LeeHaeryoung Kim

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