PMID: 7541642May 1, 1995Paper

Allelic losses in human chromosome 11 in lung cancers

Genes, Chromosomes & Cancer
M IizukaT Sekiya

Abstract

The relatively frequent loss of heterozygosity at loci on the short arm of chromosome 11 in human lung cancers has suggested the presence of a putative tumor suppressor gene. For location of the gene, a fine deletion map of human chromosome 11 was constructed by analysis of DNAs from 79 lung cancers with 31 sequence-tagged-site markers that dotted chromosome 11 and detected polymorphic changes in nucleotide sequences. The results showed that three regions, 11p12-p15, 11q12, and 11q14-q24, were commonly deleted in a considerable number of cancers, indicating the possible presence of more than one tumor suppressor gene. The range of deletion in the 11p15 region was estimated to be 4.5 megabases. That in the 11q24-q24 region was divided into two portions: one was 3 cM in length, and the other was longer and could not be specified because of lack of appropriate markers. The deletion in the 11q12 region was so short that two markers flanking the region could not be identified by genetic analysis.

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Citations

May 26, 1999·The Journal of Pathology·J KorethJ O McGee
Sep 18, 1998·Biochimica Et Biophysica Acta·Y SekidoJ D Minna
Sep 25, 2003·Proceedings of the National Academy of Sciences of the United States of America·Eric S MartinCarlo M Croce
Jul 8, 1998·Proceedings of the National Academy of Sciences of the United States of America·Y MurakamiR H Reeves
Jan 1, 1996·Progress in Histochemistry and Cytochemistry·J C Alers, H van Dekken
Aug 20, 2003·International Journal of Cancer. Journal International Du Cancer·Takeshi FukamiYoshinori Murakami
Jul 4, 2006·Biochemical and Biophysical Research Communications·Kyoko ShimizuToshifumi Tsujiuchi
Jun 15, 1997·Genomics·T ImaiT Hori
May 7, 2002·Molecular Therapy : the Journal of the American Society of Gene Therapy·Guang-ping GaoJames M Wilson
Mar 30, 2001·Nature Genetics·M KuramochiY Murakami
Feb 18, 1999·Oncogene·J KorethJ O McGee
Nov 27, 1995·International Journal of Cancer. Journal International Du Cancer·T Shimizu, T Sekiya
Nov 25, 2000·Laboratory Investigation; a Journal of Technical Methods and Pathology·M TokunouS Hirohashi

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