Allelic polymorphism in the hamster oviductin gene is due to a variable number of mucin-like tandem repeats

Molecular Reproduction and Development
Y PaquetteG Bleau

Abstract

Oviductins are high-molecular-weight glycoproteins specifically secreted by the oviduct. These proteins bind to the zona pellucida of the ovulated oocyte and remain associated with the embryo during its transit in the oviduct. They may be involved in fertilization and early embryonic development. In order to explore their putative biological function, the cDNA sequence corresponding to oviductin in the golden hamster was determined. We found that the deduced amino acid sequence of this heavily O-glycosylated protein presents characteristics typical of mucins, including serine- or threonine-rich tandem repeats. Analysis of several cDNA clones and of genomic DNA revealed the presence of a single copy gene with two frequent alleles differing in the number of repeats. Comparison with oviductin sequences from other mammals indicates a high degree of conservation amongst species, except for the repeat region which shows divergence, notably in the number of repeats. Based on its biochemical and genetic properties, hamster oviductin can now be classified as a secretory mucin. This concept provides a new insight in the elucidation of its biological role: oviductin could possibly provide the oviduct and the oocyte with a protective coati...Continue Reading

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Citations

Mar 1, 1997·Molecular Reproduction and Development·E RouxF W Kan
Oct 3, 2000·Molecular Reproduction and Development·Y Merlen, G Bleau
Feb 25, 1991·Neuroscience Letters·M ShimojoS Kohsaka
Oct 28, 1997·Fertility and Sterility·L LapenséeG Bleau
Jun 30, 2010·Molecular Human Reproduction·Manuel AvilésPilar Coy
Dec 23, 2020·Biomolecules·Leopoldo González-BrusiMaria Jiménez-Movilla
Jan 8, 2000·The Journal of Biological Chemistry·M OwhashiN Hayai

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