Allelic variability in D21S11, but not in APP or APOE, is associated with cognitive decline in Down syndrome

Neuroreport
M J FarrerA M Kessling

Abstract

Genetic variation in the APOE gene and variation in chromosome 21 genotypes, including the APP locus, may influence age-associated cognitive decline in adults with Down syndrome. Molecular genetic and longitudinal neuropsychological analysis was performed for 41 unrelated Caucasian individuals (mean age 48.1 +/- 1.1 years (s.c.m.)) with free trisomy 21. Allele frequencies and genotype distributions were compared among subgroups with or without evidence of cognitive decline. Genetic variability at APOE and APP was not significantly associated with evidence of cognitive decline. However, aged individuals with Down syndrome, without evidence of cognitive decline, demonstrated unusual allelic variability at D21S11. These findings are discussed in the context of current hypotheses of Alzheimer-type dementia in Down syndrome and in the general population.

References

May 11, 1991·Lancet·J de BoerG G Persijn
May 11, 1991·Lancet·P R WenhamG Blandell
Jan 1, 1991·Acta Neuropathologica·H Braak, E Braak
Sep 12, 1995·Proceedings of the National Academy of Sciences of the United States of America·G D Schellenberg
Sep 18, 1993·Lancet·S NoguchiN Yamada

❮ Previous
Next ❯

Citations

Jul 19, 2000·Mental Retardation and Developmental Disabilities Research Reviews·R S Chapman, L J Hesketh
Mar 20, 1998·Annals of Neurology·V P PrasherA C Butler
Jul 23, 1999·Experimental Neurology·A Petronis
Jun 22, 2000·American Journal of Medical Genetics·S MoalemA C Warren
Apr 13, 2006·IUBMB Life·Francesca ArgellatiRoberta Ricciarelli
May 2, 2002·The British Journal of Psychiatry : the Journal of Mental Science·Nicole Schupf, Gertrude H Sergievsky
Oct 1, 2020·Alzheimer's & Dementia : Diagnosis, Assessment & Disease Monitoring·Sigan L HartleyBradley T Christian

❮ Previous
Next ❯

Related Concepts

Related Feeds

Alzheimer's Disease: APP

Amyloid precursor protein (APP) proteolysis is critical for the development of Alzheimer's disease, a neurodegenerative disease associated with accumulation of amyloid plaques in the brain. Here is the latest research on APP and Alzheimer's disease.

Alzheimer's Disease: APOE

Apolipoprotein E (APOE) polymorphic alleles are major genetic risk factors for Alzheimer's disease. Discover the latest research on APOE and other genetic determinants of Alzheimer's disease here.

Alzheimer's Disease: Amyloid Beta

Alzheimer's disease is a neurodegenerative disease associated with the accumulation of amyloid plaques in the brain; these plaques are comprised of amyloid beta deposits. Here is the latest research in this field.

Age-related Dementia

Dementias are a group of conditions, including Alzheimer's disease, vascular dementia, and frontotemporal dementia, characterized by deficiencies in cognitive abilities. Age-related dementia refers to dementias that occur in older individuals, usually 60+ years old, in contrast to early-onset dementia. Follow the latest research on age-related dementia here.

Aging Epidemiology

This feed focuses on epidemiology of aging and aging-related conditions, including Alzheimer’s disease, dementia, and age-associated cognitive impairment. Here is the latest research.

ApoE Phenotypes

Apolipoprotein E (APOE) is a protein involved in fat metabolism and associated with the pathogenesis of Alzheimer's disease and cardiovascular disease. Here is the latest research on APOE phenotypes.