Allelic variation in 5-HTTLPR and the effects of citalopram on the emotional neural network

The British Journal of Psychiatry : the Journal of Mental Science
Yina MaShihui Han

Abstract

Selective serotonin reuptake inhibitors (SSRIs), such as citalopram, which selectively block serotonin transporter (5-HTT) activity, are widely used in the treatment of depression and anxiety disorders. Numerous neuroimaging studies have examined the effects of SSRIs on emotional processes. However, there are considerable inter-individual differences in SSRI effect, and a recent meta-analysis further revealed discrepant effects of acute SSRI administration on neural responses to negative emotions in healthy adults. We examined how a variant of the serotonin-transporter polymorphism (5-HTTLPR), which affects the expression and function of 5-HTT, influenced the acute effects of an SSRI (citalopram) on emotion-related brain activity in healthy adults. Combining genetic neuroimaging, pharmacological technique and a psychological paradigm of emotion recognition, we scanned the short/short (s/s) and long/long (l/l) variants of 5-HTTLPR during perception of fearful, happy and neutral facial expressions after the acute administration of an SSRI (i.e. 30 mg citalopram administered orally) or placebo administration. We found that 5-HTTLPR modulated the acute effects of citalopram on neural responses to negative emotions. Specifically, re...Continue Reading

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Citations

Sep 20, 2015·Social Cognitive and Affective Neuroscience·Siyang LuoShihui Han
Jun 17, 2016·Expert Opinion on Drug Metabolism & Toxicology·Chiara FabbriAlessandro Serretti
Oct 20, 2017·Social Cognitive and Affective Neuroscience·Danyang WangYina Ma
Mar 26, 2015·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Yina MaShihui Han
Jul 4, 2019·Proceedings of the National Academy of Sciences of the United States of America·Andrea M SantangeloAngela C Roberts

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