Allelic variation of the Tas1r3 taste receptor gene affects sweet taste responsiveness and metabolism of glucose in F1 mouse hybrids

PloS One
Vladimir O MurovetsV A Zolotarev

Abstract

In mammals, inter- and intraspecies differences in consumption of sweeteners largely depend on allelic variation of the Tas1r3 gene (locus Sac) encoding the T1R3 protein, a sweet taste receptor subunit. To assess the influence of Tas1r3 polymorphisms on feeding behavior and metabolism, we examined the phenotype of F1 male hybrids obtained from crosses between the following inbred mouse strains: females from 129SvPasCrl (129S2) bearing the recessive Tas1r3 allele and males from either C57BL/6J (B6), carrying the dominant allele, or the Tas1r3-gene knockout strain C57BL/6J-Tas1r3tm1Rfm (B6-Tas1r3-/-). The hybrids 129S2B6F1 and 129S2B6-Tas1r3-/-F1 had identical background genotypes and different sets of Tas1r3 alleles. The effect of Tas1r3 hemizygosity was analyzed by comparing the parental strain B6 (Tas1r3 homozygote) and hemizygous F1 hybrids B6 × B6-Tas1r3-/-. Data showed that, in 129S2B6-Tas1r3-/-F1 hybrids, the reduction of glucose tolerance, along with lower consumption of and lower preference for sweeteners during the initial licking responses, is due to expression of the recessive Tas1r3 allele. Hemizygosity of Tas1r3 did not influence these behavioral and metabolic traits. However, the loss of the functional Tas1r3 allel...Continue Reading

References

Jan 1, 1974·The Journal of Heredity·J L Fuller
Aug 1, 1997·Mammalian Genome : Official Journal of the International Mammalian Genome Society·A A BachmanovG K Beauchamp
Sep 7, 1999·Physiology & Behavior·M E Frank, D A Blizard
Aug 18, 2001·Cell·G NelsonC S Zuker
Sep 14, 2001·Chemical Senses·A A BachmanovG K Beauchamp
Jul 19, 2003·Science·Sami DamakRobert F Margolskee
Nov 26, 2003·Cell·Grace Q ZhaoCharles S Zuker
Jan 30, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·D R ReedA A Bachmanov
Mar 6, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Masashi InoueAlexander A Bachmanov
Sep 2, 2005·Chemical Senses·John I GlendinningKun Hao Zheng
Jun 28, 2006·Chemical Senses·Un-kyung KimDennis Drayna
Aug 29, 2007·Proceedings of the National Academy of Sciences of the United States of America·Hyeung-Jin JangJosephine M Egan
Aug 29, 2007·Proceedings of the National Academy of Sciences of the United States of America·Robert F MargolskeeSoraya P Shirazi-Beechey
Dec 22, 2007·NeuroImage·Guido K W FrankWalter H Kaye
Apr 10, 2008·Diabetes·Eric D BerglundDavid H Wasserman
Jul 2, 2008·The Journal of General Physiology·Tim J CraigPeter Proks
Aug 9, 2008·Omics : a Journal of Integrative Biology·Bibiana Garcia-BailoAhmed El-Sohemy
Jul 3, 2009·The American Journal of Clinical Nutrition·Zaza KokrashviliRobert F Margolskee
Jul 30, 2009·American Journal of Physiology. Endocrinology and Metabolism·Owen P McGuinnessDavid H Wasserman
Oct 27, 2010·PLoS Genetics·Ni HuangMatthew E Hurles
Mar 8, 2011·Physiology & Behavior·Yada TreesukosolAlan C Spector
Jul 12, 2011·Flavour and Fragrance Journal·Alexander A BachmanovGary K Beauchamp
Nov 24, 2011·Diabetes & Metabolism Journal·Itaru Kojima, Yuko Nakagawa
Feb 9, 2012·Proceedings of the National Academy of Sciences of the United States of America·George A KyriazisBjörn Tyrberg
Mar 14, 2012·Proceedings of the National Academy of Sciences of the United States of America·Peihua JiangGary K Beauchamp
Mar 28, 2012·Protein Expression and Purification·Elodie MaîtrepierreLoïc Briand
Jun 6, 2012·Appetite·Anthony Sclafani
Jun 12, 2012·Physiology & Behavior·John I GlendinningAnthony Sclafani
Sep 11, 2012·Molecular Cell·Eric M WausonMelanie H Cobb
Sep 18, 2012·Applied Microbiology and Biotechnology·Maud SigoillotLoïc Briand
Dec 4, 2012·American Journal of Physiology. Gastrointestinal and Liver Physiology·Kristian DalySoraya P Shirazi-Beechey
Jan 28, 2014·PloS One·Becky R SimonOrmond A MacDougald
Apr 26, 2014·Current Opinion in Clinical Nutrition and Metabolic Care·Anni LaffitteLoïc Briand
May 20, 2015·Journal of Evolutionary Biochemistry and Physiology·V O MurovetsV A Zolotarev
Jun 25, 2015·PloS One·Vladimir O MurovetsVasiliy A Zolotarev
Jul 15, 2015·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·John I GlendinningAnthony Sclafani

❮ Previous
Next ❯

Methods Mentioned

BETA
sedation

Software Mentioned

Statistica

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2021 Meta ULC. All rights reserved