Allelic variation within the putative autism spectrum disorder risk gene homeobox A1 and cerebellar maturation in typically developing children and adolescents.

Autism Research : Official Journal of the International Society for Autism Research
Armin RaznahanJay N Giedd

Abstract

Homeobox A1 (HOXA1) has been proposed as a candidate gene for autism spectrum disorder (ASD) as it regulates embryological patterning of hind-brain structures implicated in autism neurobiology. In line with this notion, a nonsynonymous single nucleotide polymorphism within a highly conserved domain of HOXA1--A218G (rs10951154)--has been linked to both ASD risk, and cross-sectional differences in superior posterior lobar cerebellar anatomy in late adulthood. Despite evidence for early onset and developmentally dynamic cerebellar involvement in ASD, little is known of the relationship between A218G genotype and maturation of the cerebellum over early development. We addressed this issue using 296 longitudinally acquired structural magnetic resonance imaging brain scans from 116 healthy individuals between 5 and 23 years of age. Mixed models were used to compare the relationship between age and semi-automated measures of cerebellar volume in A-homozygotes (AA) and carriers of the G allele (Gcar). Total cerebellar volume increased between ages of 5 and 23 years in both groups. However, this was accelerated in the Gcar relative to the AA group (Genotype-by-age interaction term, P = 0.03), and driven by genotype-dependent differences...Continue Reading

References

Feb 24, 1977·Nature·S Folstein, M Rutter
May 1, 1986·Journal of Clinical Periodontology·N W Chilton, J L Fleiss
Feb 1, 1995·Journal of Autism and Developmental Disorders·T HashimotoY Kuroda
Jun 24, 1996·The Journal of Comparative Neurology·P M RodierJ Romano
Sep 17, 1999·Journal of Child Neurology·A T Yachnis, L B Rorke
Sep 24, 1999·Nature Neuroscience·J N GieddJ L Rapoport
Feb 24, 2001·Behavior Genetics·D PosthumaD Boomsma
Mar 17, 2001·Nature Reviews. Neuroscience·P A Trainor, R Krumlauf
Jul 4, 2001·Nature Reviews. Neuroscience·V Y Wang, H Y Zoghbi
Apr 23, 2002·Human Mutation·J Ross HawkinsThomas A Weaver
Jun 21, 2002·Computerized Medical Imaging and Graphics : the Official Journal of the Computerized Medical Imaging Society·Vincent A MagnottaDan Heckel
Sep 5, 2002·American Journal of Medical Genetics·Bernie DevlinUNKNOWN Collaborative Programs of Excellence in Autism (CPEA) Genetics Network
Nov 5, 2002·Journal of Medical Genetics·Z TalebizadehM G Butler
Dec 17, 2002·NeuroImage·Ronald PiersonNancy C Andreasen
Apr 17, 2003·British Medical Bulletin·Ahmad R Hariri, Daniel R Weinberger
May 16, 2003·Development Genes and Evolution·J M McClintockV E Prince
Aug 12, 2003·Journal of Autism and Developmental Disorders·Julianne S CollinsRon C Michaelis
Aug 28, 2003·Journal of Child Neurology·Walter E KaufmannDiane C Lanham
Feb 13, 2004·Biological Psychiatry·Monica ConciatoriAntonio M Persico
Aug 27, 2004·Brain : a Journal of Neurology·Saskia J M C PalmenChristoph Schmitz
Mar 8, 2005·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Margaret L Bauman, Thomas L Kemper
Aug 3, 2005·Cellular and Molecular Neurobiology·Z N Akin, A J Nazarali
Aug 20, 2005·Developmental Medicine and Child Neurology·A D RasalamJ C S Dean
Sep 20, 2005·Biochemical and Biophysical Research Communications·Rubigilda C ParaguisonEiji Nanba
Nov 1, 2006·Journal of Child Psychology and Psychiatry, and Allied Disciplines·Gregory L WallaceJay N Giedd
Dec 15, 2006·Psychiatric Genetics·Barsha SenRajamma Usha
Dec 16, 2006·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Lucia Anna MuscarellaAntonio M Persico
Jun 6, 2007·Archives of General Psychiatry·Thomas H WassinkJoseph Piven
Sep 4, 2007·European Psychiatry : the Journal of the Association of European Psychiatrists·Andrew C StanfieldStephen M Lawrie
Apr 19, 2008·Journal of the International Neuropsychological Society : JINS·Howard B CleavingerJanet E Lainhart
Nov 21, 2008·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·Elisa CanuGiovanni B Frisoni
Feb 27, 2009·Psychiatry Research·Sara Jane WebbStephen R Dager
Mar 19, 2009·Nature Reviews. Genetics·Kelly A FrazerEric J Topol
Jul 15, 2009·Autism Research : Official Journal of the International Society for Autism Research·B ChakrabartiS Baron-Cohen
Jul 17, 2009·The American Journal of Psychiatry·Shanti R MitchellWendy R Kates
Jun 12, 2010·Psychological Medicine·A Meyer-Lindenberg
Sep 1, 2009·Journal of Neurodevelopmental Disorders·Armin RaznahanDeclan G M Murphy

❮ Previous
Next ❯

Citations

Feb 21, 2013·Translational Psychiatry·S J JamesI P Pogribny
Jun 19, 2013·Behavioural Brain Research·Antonio M Persico, Valerio Napolioni
Jan 1, 2012·Scientifica·Gene J Blatt
Jul 12, 2014·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Leanna M HernandezMirella Dapretto

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autism

Autism spectrum disorder is associated with challenges with social skills, repetitive behaviors, and often accompanied by sensory sensitivities and medical issues. Here is the latest research on autism.

Related Papers

Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging
Elisa CanuGiovanni B Frisoni
American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics
Lucia A MuscarellaAntonio M Persico
© 2022 Meta ULC. All rights reserved