Allelic variations in the vitamin D receptor gene, insulin secretion and parents' heights are independently associated with height in obese children and adolescents

Metabolism: Clinical and Experimental
Daniela A F FerrareziSandra M Villares

Abstract

Polymorphisms in the VDR gene were reported to be associated with variations in intrauterine and postnatal growth and with adult height, but also with other traits that are strongly correlated such as the BMI, insulin sensitivity, insulin secretion and hyperglycemia. Here, we assessed the impact of VDR polymorphisms on body height and its interactions with obesity- and glucose tolerance-related traits in obese children and adolescents. We studied 173 prepubertal (Tanner's stage 1) and 146 pubertal (Tanner's stages 2-5) obese children who were referred for a weight-loss program. Three single nucleotide polymorphisms were genotyped: rs1544410 (BsmI), rs7975232 (ApaI) and rs731236 (TaqI). BsmI and TaqI genotypes were significantly associated with height in pubertal children, but the associations did not reach statistical significance in prepubertal children. In stepwise regression analyses, the lean body mass, insulin secretion, BsmI or TaqI genotypes and the father's and the mother's height were independently and positively associated with height in pubertal children. These covariables accounted for 46% of the trait variance. The height of homozygous carriers of the minor allele of BsmI was 0.65 z-scores (4cm) higher than the hei...Continue Reading

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Citations

Feb 18, 2016·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Norah AlmesriHayder Ahmed Giha
Sep 21, 2013·Metabolism: Clinical and Experimental·Anand Vaidya
Oct 18, 2016·Critical Reviews in Food Science and Nutrition·Kelly Virecoulon GiudiciLígia Araújo Martini
Apr 27, 2017·Journal of the American College of Nutrition·Kelly Virecoulon GiudiciLígia Araújo Martini
Jan 21, 2021·International Journal of General Medicine·Di WangChunlin Wang
Feb 9, 2021·Journal of Diabetes and Metabolic Disorders·Buthaina E AlathariKarani Santhanakrishnan Vimaleswaran

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