PMID: 9426686Jan 14, 1998Paper

Allelotype analysis of hepatocellular carcinoma

International Journal of Cancer. Journal International Du Cancer
Z PiaoH Kim

Abstract

To elucidate the genetic events which may play important roles in hepatocarcinogenesis, we examined every non-acrocentric chromosome arm of 22 hepatocellular carcinomas (HCCs) for loss of heterozygosity (LOH) using 68 highly polymorphic microsatellite markers. Thirty-six (92%) of 39 chromosome arms showed LOH in at least one patient, however 3 chromosome arms, 2p, 2q, and 20q, did not show any LOH. High to moderate frequency of LOH (> 30% of informative cases) was observed at chromosomes 1q (68.1%), 4q (72.7%), 8p (63.6%), 8q (77.3%), 10q (33.3%), 13q (40%), 14q (46.1%), 16q (59.1%), and 17p (46.2%). Among these, LOH on chromosomes 1q and 8q have not been previously identified in HCC. Our results suggest that novel tumor suppressor genes may be involved in the development and progression of HCC.

References

Jul 30, 1992·International Journal of Cancer. Journal International Du Cancer·N NishidaK Ishizaki
Apr 14, 1989·Science·B VogelsteinR White
Sep 1, 1988·The New England Journal of Medicine·B VogelsteinJ L Bos
Jan 1, 1986·Annual Review of Biochemistry·J F Gusella
Mar 1, 1995·Journal of Gastroenterology and Hepatology·Y YumotoT Tsuji
Dec 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·A G Knudson
Aug 1, 1993·Japanese Journal of Cancer Research : Gann·M KonishiN Hattori
Jul 3, 1996·International Journal of Cancer. Journal International Du Cancer·J A KrausT Pietsch

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Citations

Dec 3, 2003·Journal of Clinical Pathology·H FujiiT Shimoda
May 27, 2005·Acta Pharmacologica Sinica·Sze-hang Lau, Xin-yuan Guan
Jun 27, 2006·Oncogene·P Laurent-Puig, J Zucman-Rossi
Mar 25, 2000·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M RoncalliG Coggi
May 5, 2000·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·H OkabeY Yamaoka
Aug 12, 2004·Journal of Gastroenterology and Hepatology·Masahiko KondoTsutomu Chiba
Sep 30, 2010·International Journal of Cancer. Journal International Du Cancer·Stephen Ho Kin ChanMaria Li Lung
Jul 26, 2005·Biochemical and Biophysical Research Communications·S A CiafrèM G Farace
Jan 20, 2005·The Medical Clinics of North America·Paul H Hayashi, Adrian M Di Bisceglie
Jan 31, 2003·Molecular Carcinogenesis·Sharon L RickettsWilliam B Coleman
Jan 31, 2003·Genes, Chromosomes & Cancer·Koichi MatsuoIwao Ikai
Jun 11, 1999·Japanese Journal of Cancer Research : Gann·N KawamuraM Emi
Apr 27, 2010·Current Problems in Cancer·Aiwu Ruth HeMajed El Zouhairi
Jan 17, 2002·Genes, Chromosomes & Cancer·Elizabeth PangPhilip J Johnson
Oct 26, 2000·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M MaggioniM Roncalli
Aug 12, 1998·International Journal of Cancer. Journal International Du Cancer·Z PiaoH Kim
May 11, 2002·Laboratory Investigation; a Journal of Technical Methods and Pathology·Luigi TornilloLuigi M Terracciano
Nov 28, 2002·British Journal of Cancer·Y-C ChangN-H Chow
Mar 24, 2007·Journal of Gastroenterology·Blake A JacobsonLance J Ferrin
Jun 9, 1999·British Journal of Cancer·Z PiaoH Kim

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