PMID: 7543503Aug 1, 1995Paper

Allergen challenge-induced entry of alpha 2-macroglobulin and tryptase into human nasal and bronchial airways

The Journal of Allergy and Clinical Immunology
C SvenssonC G Persson

Abstract

Microvascular-epithelial exudation of bulk plasma may characterize inflammatory airway diseases. This study compares the acute allergen challenge-induced mast cell and exudative responses in nasal and bronchial airways. The focus is on alpha 2-macroglobulin as an index of luminal entry of plasma exudates. Separate nasal and bronchial allergen challenges were carried out outside the pollen season in eight patients with pollen-induced seasonal allergic rhinitis. The levels of different-sized plasma proteins (albumin molecular weight, 66,000 d and alpha 2-macroglobulin molecular weight, 725,000 d) and tryptase were determined in pre- and postchallenge nasal lavage and bronchoalveolar lavage (BAL) fluids. Diluent and increasing doses of allergen were sprayed into the right nasal cavity, and each challenge was followed by a nasal lavage (volume, 15 ml) with a "nasal pool" device (recovery, > 80%). Endobronchial allergen challenge (individual doses) and BAL (volume, 2 x 25 ml) were performed in a lobe bronchus through a fiberoptic bronchoscope (recovery, 30%). Saline challenge and BAL were carried out in the contralateral lung as control. The levels of albumin, alpha 2-macroglobulin, and tryptase increased dose-dependently in postcha...Continue Reading

Citations

Mar 5, 2005·Bioorganic & Medicinal Chemistry Letters·Montserrat del FresnoFernando Albericio
Mar 5, 2005·The Journal of Allergy and Clinical Immunology·Peter H HowarthPhilip E Silkoff
Jul 3, 2007·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Cengiz KirmazHasan Yuksel
Jan 20, 1998·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·J S ErjefältC G Persson
Apr 16, 1998·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·H H JacobiN Mygind
May 11, 2002·Clinical Physiology and Functional Imaging·Lennart GreiffCarl G A Persson
May 26, 1998·Scandinavian Journal of Immunology·C G PerssonC Svensson
Feb 5, 2011·International Archives of Allergy and Immunology·Franziska RuëffBernhard Przybilla
Dec 31, 1997·American Journal of Respiratory and Critical Care Medicine·T J HiltermannP S Hiemstra
Jul 3, 1999·American Journal of Respiratory and Critical Care Medicine·J S ErjefältC G Persson
Oct 6, 2010·Respiratory Research·Andrea ZaniniDario Olivieri
Jul 20, 2010·Current Opinion in Biotechnology·Ming Je HsiehColin W Pouton
Jun 14, 2005·Respiratory Medicine·Louis-Philippe BouletMichel Laviolette
Apr 9, 2020·Expert Review of Proteomics·Peter Valentin TomazicRuth Birner-Gruenberger
Dec 8, 1998·Journal of Applied Physiology·I T LauredoW M Abraham
Mar 26, 1998·American Journal of Rhinology·C SvenssonC G Persson
Aug 12, 1999·Archives of Biochemistry and Biophysics·M WalterN M Schechter
Mar 24, 2020·Journal of Innate Immunity·Carl Persson

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology
C G PerssonC Svensson
Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology
C SvenssonC G Persson
The American Review of Respiratory Disease
P SalomonssonC G Persson
American Journal of Respiratory and Critical Care Medicine
J S ErjefältC G Persson
© 2021 Meta ULC. All rights reserved