Allergen immunotherapy as add-on to biologic agents

Current Opinion in Allergy and Clinical Immunology
Carlo LombardiGiovanni Passalacqua

Abstract

In this review, we sought to outline many of the recent evidences about the available clinical trials in which biologic agents [i.e. omalizumab (OMA)] were associated as add-on to allergen-specific immunotherapy (AIT). The available literature shows that OMA may be a valuable option as add-on to AIT for respiratory allergy, or food desensitization, especially in the escalation or build-up phases, in which adverse events are more commonly expected. The encouraging data for hymenoptera venom allergy remain limited to case reports, and no structured clinical trial is available. Over the past decade, studies of OMA used with AIT have shown promising results. Today, big randomized, double-blind, placebo-controlled trials are needed to better select those patients who would benefit from the addition of OMA (or other biologic agents) to AIT, as well as optimal dosing schedules, optimal duration of treatments and, finally, adequate evaluation about pharmacoeconomic aspects.

References

Apr 18, 2001·International Archives of Allergy and Immunology·R J van NeervenF M Davis
Nov 6, 2002·The Journal of Allergy and Clinical Immunology·Matthias Volkmar KoppJoachim Kuehr
Mar 15, 2003·The New England Journal of Medicine·Donald Y M LeungUNKNOWN Avon Longitudinal Study of Parents and Children Study Team
Nov 13, 2003·Current Opinion in Allergy and Clinical Immunology·Eckard HamelmannUlrich Wahn
Nov 18, 2003·Allergy·P A Eigenmann
Feb 10, 2004·The Journal of Allergy and Clinical Immunology·Francisque LeynadierPatrick Trunet
Jul 14, 2004·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·C BezS Zielen
Jan 3, 2006·The Journal of Allergy and Clinical Immunology·Thomas B CasaleUNKNOWN Immune Tolerance Network Group
Jan 3, 2006·The Journal of Allergy and Clinical Immunology·Hetal S AminDavid I Bernstein
Jul 17, 2007·The Journal of Allergy and Clinical Immunology·Sven KlunkerUNKNOWN Immune Tolerance Network Group
Nov 21, 2007·BioDrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy·Philippe StockEckard Hamelmann
May 1, 2008·Allergy·M OlivieriL Perbellini
Nov 20, 2008·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·M V KoppUNKNOWN DUAL study group
Sep 8, 2009·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Wolfgang KaminUlrich Wahn
Feb 18, 2010·The Journal of Allergy and Clinical Immunology·Marc MassanariRobert K Zeldin
Aug 3, 2010·The Journal of Allergy and Clinical Immunology·Hana M TartibiDavid A Khan
Nov 6, 2010·The Journal of Allergy and Clinical Immunology·Mascha K RochatUNKNOWN Multicentre Allergy Study (MAS) group
Dec 3, 2010·The Journal of Allergy and Clinical Immunology·Linda CoxDana Wallace
May 7, 2011·The Journal of Allergy and Clinical Immunology·Kari C NadeauDale T Umetsu
Jun 27, 2013·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Matthias Volkmar KoppUNKNOWN DUAL study group
Sep 18, 2013·JAMA Pediatrics·Ruchi GuptaDavid Meltzer
Oct 15, 2013·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·T UmasuntharR J Boyle
Nov 2, 2013·The Journal of Allergy and Clinical Immunology·Lynda C SchneiderDale T Umetsu
Jan 17, 2014·Allergy, Asthma, and Clinical Immunology : Official Journal of the Canadian Society of Allergy and Clinical Immunology·Philippe BéginKari C Nadeau
Jan 23, 2014·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·F RuëffM Flaig
Feb 26, 2014·The Journal of Allergy and Clinical Immunology. in Practice·Elizabeth Nicole da Silva, Katrina Louise Randall
Mar 29, 2014·International Journal of Immunopathology and Pharmacology·K PalganM Gotz-Zbikowska
May 9, 2014·The Journal of Allergy and Clinical Immunology. in Practice·Sophia TsabouriEvangelia E Ntzani
Jun 7, 2014·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Isabel LafuenteAntonio Nieto
Aug 15, 2014·Current Opinion in Allergy and Clinical Immunology·Gianna MoscatoJoaquin Sastre
Sep 14, 2014·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Katherine S Tille, Amy L Parker
Jan 13, 2015·Expert Review of Respiratory Medicine·Fulvio BraidoGiorgio Walter Canonica
Jun 13, 2015·Allergy, Asthma, and Clinical Immunology : Official Journal of the Canadian Society of Allergy and Clinical Immunology·Masaya TakahashiKazunari Kaneko
Mar 24, 2016·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·C Martorell-CalatayudM D De Las Marinas-Álvarez
Apr 14, 2016·Current Opinion in Allergy and Clinical Immunology·Matthew Greenhawt
Apr 27, 2016·JAMA : the Journal of the American Medical Association·J Christian VirchowFrederic de Blay
Aug 17, 2016·The Journal of Allergy and Clinical Immunology. in Practice·Giovanni PassalacquaGiorgio Walter Canonica
Oct 19, 2016·The Journal of Allergy and Clinical Immunology·Andrew J MacGinnitieLynda C Schneider
Sep 30, 2016·International Journal of Immunopathology and Pharmacology·L Ricciardi
Nov 2, 2016·Clinical and Molecular Allergy : CMA·Elisa BoniMarina Mauro
Nov 9, 2016·Allergy, Asthma & Immunology Research·Matteo FerrandoGiorgio Walter Canonica
Nov 25, 2016·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·J BrandströmA Nopp
Dec 3, 2016·Current Opinion in Allergy and Clinical Immunology·Tanvi R Patel, Sanjiv Sur

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Citations

Jan 12, 2019·Expert Opinion on Drug Metabolism & Toxicology·Diego BagnascoGiorgio Walter Canonica
Sep 6, 2019·Scandinavian Journal of Immunology·Célia CostaAna Todo-Bom
Nov 13, 2019·Allergy·Giovanni PassalacquaGiorgio Walter Canonica
Feb 26, 2019·Frontiers in Pediatrics·Stefania ArasiAlessandro G Fiocchi
Dec 29, 2020·Current Opinion in Allergy and Clinical Immunology·Oluwatoyin AkinfenwaRaffaela Campana
May 11, 2021·The Journal of Allergy and Clinical Immunology. in Practice·Oliver PfaarStefan Schülke

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